[09 January 2014]
Products Affected - Description
Multivitamin for infusion (MVI) Adult, Hospira
MVI Adult, 10 mL two-chambered vials (NDC 61703-0422-81)
MVI Adult, 2 x 5 mL Dual vials (NDC 61703-0422-82)
MVI Adult, 2 x 50 mL Dual vials (NDC 61703-0422-83)
Multivitamin for infusion (MVI) Without Vitamin K Adult, Hospira
MVI-12 Adult, 10 mL two-chambered vials (NDC 61703-0423-81)
MVI-12 Adult, 50 mL Dual vials (NDC 61703-0423-83)
Multivitamin for infusion (MVI) Pediatric, Hospira
MVI Pediatric, lyophilized powder, 5 mL (once reconstituted) vials (NDC 61703-0421-53)
Infuvite for infusion, Baxter
Adult 2 x 5 mL single dose vials (NDC 54643-5649-01)
Adult 2 x 50 mL bulk vials (NDC 54643-5650-02)
Pediatric 5 mL single dose vials (NDC 54643-5646-01)
Pediatric 50 mL bulk vials (NDC 54643-5647-00)
Reason for the Shortage
- Hospira states the shortage is due to manufacturing delays.
- Baxter states the reason for the shortage is manufacturing delays. Sandoz manufacturers Infuvite pediatric for Baxter. In February, 2012 Sandoz notified Baxter it was suspending production of the Infuvite pediatric 5 mL vials indefinitely. Infuvite pediatric 50 mL vials will continue to be available.
- Baxter discontinued NDC 54643-5649-02 in March 2012.
There are insufficient supplies for usual ordering.
Estimated Resupply Dates
- Hospira has all adult multivitamin for infusion on back order and cannot estimate a release date. Hospira has limited supplies of pediatric multivitamin for infusion.
- Baxter has Infuvite adult 2 x 5 mL vials on intermittent back order and the company is releasing product as it becomes available. Infuvite adult 2 x 50 mL vials are on back order and the company estimates a release date in March 2014. Infuvite pediatric 50 mg bulk vials are on allocation. Infuvite pediatric 5 mL vials are temporarily suspended from manufacturing and the company cannot estimate a release date.
Alternative Agents & Management
- The American Society for Parenteral and Enteral Nutrition (ASPEN) has detailed recommendations for managing an intravenous multivitamin shortage in adults and pediatric patients online.
- Key recommendations include:
- Use oral or enteral multivitamin preparations whenever possible.
- Use of pediatric intravenous multivitamins for adults is not recommended and may result in a shortage of pediatric products.
- Use of multivitamin preparations without vitamin K is fine with individual supplementation of Vitamin K products. Ensure patients receiving vitamin K are getting adequate anticoagulation if they are on warfarin.
- Reserve intravenous multivitamins for patients receiving parenteral nutrition.
- Reserve pediatric intravenous multivitamins for children less than 2.5 kg or less than 36 weeks gestational age.
- When all supply options are exhausted, ration intravenous multivitamins in parenteral nutrition or administer individual parenteral vitamins.
- Purchase only the supply needed, do not stockpile.
January 9, 2014; October 7, 2013; August 21, 2013; August 5, 2013; June 18, 2013; May 3, 2013; April 15, 2013; February 26, 2013; January 30, 2013; December 12, 2012; October 10, 2012; September 10, 2012; September 5, 2012; August 9, 2012; July 18, 2012; May 24, 2012; May 16, 2012; April 13, 2012; March 9, 2012; February 24, 2012; January 18, 2012; January 3, 2012; December 13, 2011; November 15, 2011; October 31, 2011; October 11, 2011; October 4, 2011; September 14, 2011; August 1, 2011; July 14, 2011; June 28, 2011; June 3, 2011; April 18, 2011; April 7, 2011; April 4, 2011; April 1, 2011; March 28, 2011, February 4, 2011; December 2, 2010; September 29, 2010; August 4, 2010; July 16, 2010; July 2, 2010; May 19, 2010; April 13, 2010; March 1, 2010; February 2, 2010; January 11, 2010; January 8, 2010; November 17, 2009; September 11, 2009, University of Utah, Drug Information Service. Copyright 2014, Drug Information Service, University of Utah, Salt Lake City, UT.
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