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Computerized Provider Order Entry (CPOE) Resources

Guidelines and Statements

Important Links

Must Read Articles

Implementation:

Medication administration quality and health information technology: a national study of US hospitals. Appari A, Carian EK, Johnson ME, Anthony DL. J Am Med Inform Assoc. 2011 Oct 28. [Epub ahead of print].
An assessment of Health Care Information and Management Systems Society and Leapfrog data on computerized provider order entry. Diana ML, Kazley AS, Menachemi N. Health Serv Res. 2011 Oct;46(5):1575-91.
Characteristics of CPOE systems and obstacles to implementation that physicians believe will affect adoption. Singh D, Spiers S, Beasley BW. South Med J. 2011 Jun;104(6):418-21.
Critical drug-drug interactions for use in electronic health records systems with computerized physician order entry: review of leading approaches. Classen DC, Phansalkar S, Bates DW. J Patient Saf. 2011 Jun;7(2):61-5.
Safe and successful implementation of CPOE for chemotherapy at a children's cancer center. Hoffman JM, Baker DK, Howard SC, Laver JH, Shenep JL.J Natl Compr Canc Netw. 2011 Feb;9 Suppl 3:S36-50.
Randomized clinical trial of a customized electronic alert requiring an affirmative response compared to a control group receiving a commercial passive CPOE alert: NSAID--warfarin co-prescribing as a test case. Strom BL, Schinnar R, Bilker W, Hennessy S, Leonard CE, Pifer E. J Am Med Inform Assoc. 2010 Jul-Aug;17(4):411-5.
Meaningful use of computerized prescriber order entry. Classen D, Bates DW, Denham CR. J Patient Saf. 2010 Mar;6(1):15-23.
Electronic prescribing at the point of care: a time-motion study in the primary care setting. Devine EB, Hollingworth W, Hansen RN. Health Serv Res. 2010 Feb;45(1):152-71.
Implementation of Computerized Physician Order Entry in Seven countries. Jos Aarts and Ross Koppel. Health Aff (Millwood). 2009 Mar-Apr;28(2):404-14.
Evaluation and Certification of Computerized Provider Order Entry Systems. David C. Classen, Anthony J. Avery, David W. Bates. J Am Med Inform Assoc. 2007;14:48-55.
Pharmacists’ perceptions of computerized prescriber-order-entry systems, Inquilla CC, Szeinbach S, Seoane-Vazquez E, Kappeler KH, Am. J. Health Syst. Pharm., Aug 2007; 64: 1626 - 1632.
Consensus Recommendations for Basic Monitoring and Evaluation of In-patient Computer-based Provider Order Entry Systems. Dean F. Sittig, Sean M. Thomas, Emily Campbell, et. al. 2007. ITCH.
Implementation of hospital computerized physician order entry systems in a rural state: Feasibility and financial impact. Ohsfeldt RL, Ward MM, Schneider JE, et.al. J Am Med Inform Assoc. 2005 Jan-Feb; 12(1): 20-7.
Hospital implementation of computerized provider order entry systems: results from the 2003 leapfrog group quality and safety survey. Hillman JM, Given RS. Journal of Healthcare Information Management. 2005; 19(4): 55-65.
Computerized prescriber order-entry systems: evaluation, selection, and implementation. Gray MD, Felkey BG. American Journal of Health System Pharmacy. 2004; 61(2): 190-7.
Strategies for pharmacy integration and pharmacy information system interfaces, Part 1: History and pharmacy integration options. Chaffee BW and Bonasso J. Am J Health Syst Pharm. March 1, 2004 61:502-506.
Strategies for pharmacy integration and pharmacy information system interfaces, Part 2: Scope of work and technical aspects of interfaces. Chaffee BW and Bonasso J. Am J Health Syst Pharm. March 1, 2004 61:506-514.
Computer physician order entry: Benefits, costs, and issues. Kuperman GJ, Gibson RF. Ann Intern Med. 2003; 139: 31-9.

Post Implementation and its Impact:

Impact of Vendor Computerized Physician Order Entry in Community Hospitals. Leung AA, Keohane C, Amato M, et. al. J Gen Intern Med. 2012 Jan 21. [Epub ahead of print]
Outcomes of computerized physician order entry in an electronic health record after implementation in an outpatient oncology setting. Harshberger CA, Harper AJ, Carro GW, et. al. J Oncol Pract. 2011 Jul;7(4):233-7.
Medication Administration Variances Before and After Implementation of Computerized Physician Order Entry in a Neonatal Intensive Care Unit. Taylor J, Loan L, Kamara J, Blackburn S, Whitney D. Pediatrics. 2008 Jan;121(1):123-128.
Return on investment for a computerized physician order entry system. Kaushal R, Jha AK, Franz C, et al. J Am Med Inform Assoc. May-June 2006; 13(3): 261-6.
Development of the Leapfrog methodology for evaluating hospital implemented inpatient computerized physician order entry systems. Qual. Saf. Health Care, April 1, 2006; 15(2): 81 - 84.
Improved compliance with quality measures at hospital discharge with a computerized physician order entry system. Butler J, Speroff T, Arbogast PG, et al. American Heart Journal. 2006; 151(3): 643-53.
Emotional aspects of computer-based provider order entry: a qualitative study. Sittig DF, Krall M, Kaalaas-Sittig J, Ash JS. Journal of the American Medical Informatics Association. 2005; 12(5): 561-7.
Adding insight: a qualitative cross-site study of physician order entry. Ash JS, Sittig DF, Seshadri V, et al. International Journal of Medical Informatics. 2005; 74(7-8): 623-8.

Patient Safety and Medication Errors:

Computerized provider order entry in pediatric oncology: design, implementation, and outcomes. Chen AR, Lehmann CU. J Oncol Pract. 2011 Jul;7(4):218-22.
Effects of therapeutic drug monitoring criteria in a computerized prescriber-order-entry system on the appropriateness of vancomycin level orders. Traugott KA, Maxwell PR, Green K, Frei C, Lewis JS 2nd. Am J Health Syst Pharm. 2011 Feb 15;68(4):347-52.
Preventing potentially inappropriate medication use in hospitalized older patients with a computerized provider order entry warning system. Mattison ML, Afonso KA, Ngo LH, Mukamal KJ. Arch Intern Med. 2010 Aug 9;170(15):1331-6.
Computerized physician order entry- based hyperglycemia inpatient protocol and glycemic outcomes: The CPOE-HIP study. Guerra YS, Das K, Antonopoulos P, et. al. Endocr Pract. 2010 May-Jun;16(3):389-97.
A Risk Analysis Method to Evaluate the Impact of a Computerized Provider Order Entry System on Patient Safety. Bonnarby P, et. al. J Am Med Inform Assoc. 2008;15:453-460.
Effects of an integrated clinical information system on medication safety in a multi-hospital setting, Mahoney CD, Berard-Collins CM, Coleman R, Amaral JF, Cotter CM, Am. J. Health Syst. Pharm., Sep 2007; 64: 1969 - 1977.
Error reduction in pediatric chemotherapy: computerized order entry and failure modes and effects analysis. Kim GR, Chen AR, et al. Arch Pediatr Adolesc Med. 2006 May;160(5):495-8.
Effect of a computerized prescriber-order-entry system on reported medication errors. Spencer DC, Leininger A, Daniels R, Granko RP, Coeytaux RR, Am. J. Health Syst. Pharm., Feb 2005; 62: 416 - 419.
Comprehensive Analysis of a Medication Dosing Error Related to CPOE. Jan Horsky, Gilad J. Kuperman, and Vimla L. Patel. J. Am. Med. Inform. Assoc. 12: 377-382
Role of Computerized Physician Order Entry Systems in Facilitating Medication Errors. Ross Koppel. Joshua P. Metlay; Abigail Cohen; Brian Abaluck; A. Russell Localio; Stephen E. Kimmel; Brian L. Strom JAMA. 2005;293(10):1197-1203.

Unintended Consequences of CPOE:

Factors contributing to an increase in duplicate medication order errors after CPOE implementation. Wetterneck TB, Walker JM, Blosky MA, Cartmill RS, Hoonakker P, Johnson MA, Norfolk E, Carayon P. J Am Med Inform Assoc. 2011 Nov-Dec;18(6):774-82.
Provider and pharmacist responses to warfarin drug-drug interaction alerts: a study of healthcare downstream of CPOE alerts. Miller AM, Boro MS, Korman NE, Davoren JB. J Am Med Inform Assoc. 2011;18:i45-i50.
Unintended effects of a computerized physician order entry nearly hard-stop alert to prevent a drug interaction: a randomized controlled trial. Strom BL, Schinnar R, Aberra F, Bilker W, Hennessy S, Leonard CE, Pifer E. Arch Intern Med. 2010 Sep 27;170(17):1578-83.
Time-dependent drug-drug interaction alerts in care provider order entry: software may inhibit medication error reductions. Van der Sijs H, Lammers L, van den Tweel A, Aarts J, Berg M, Vulto A, van Gelder T. J Am Med Inform Assoc. 2009 Nov-Dec;16(6):864-8.
The unintended consequences of computerized provider order entry: Findings from a mixed methods exploration, Ash JS, Sittig DF, Dykstra R, Campbell E, Guappone K. Int J Med Inform. 2009 April. 78:1:S69-S76.
Medication administration discrepancies persist despite electronic ordering. FitzHenry F, Peterson JF, Arrieta M, Waitman LR, Schildcrout JS, Miller RA. J Am Med Inform Assoc. 2007 Nov-Dec;14(6):756-64.
The extent and importance of unintended consequences related to computerized provider order entry. Ash JS, Sittig DF, Poon EG, Guappone K, Campbell E, Dykstra RH. J Am Med Inform Assoc. 2007 Jul-Aug;14(4):415-23.
In reply to: "e-Iatrogenesis: The most critical consequence of CPOE and other HIT". Emily M. Campbell, Dean F. Sittig, Joan S. Ash, Kenneth P. Guappone, Richard H. Dykstra. J Am Med Inform Assoc. 2007;14:389.
Types of Unintended Consequences Related to Computerized Provider Order Entry. Emily M. Campbell, Dean F. Sittig, Joan S. Ash, Kenneth P. Guappone,Richard H. Dykstra. J Am Med Inform Assoc. 2006;13:547-556.
Unexpected increased mortality after implementation of a commercially sold computerized physician order entry system. Han YY, Carcillo JA, Venkataraman ST, Clark RS, Watson RS, Nguyen TC, Bayir H, Orr RA.Pediatrics. 2005; 116(6): 1506-12.

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