Methotrexate Injection

27 October 2009

Products Affected - Description

Reason for the Shortage

Methotrexate injection is in short supply because of manufacturing delays.

Estimated Resupply Dates

• APP has the 25 mg/mL (with preservative) 10 mL vial (NDC 63323-0123-10) available. The 25 mg/mL (with preservative) 2 mL vial has been discontinued.
• Bedford has the preservative-free 2 mL, 4 mL, 8 mL, and 10 mL sizes on back order and the company cannot estimate a release date.
• Hospira (formerly Mayne) has the 25 mg/mL 2-mL vials (preservative-free [NDC 61703-0350-38]) and 40-mL vials (preservative-free [NDC 61703-0408-41]) available.
• Generamedix has available the 25 mg/mL preservative free 10-mL vials (NDC 10139-0062-10) and 40-mL vials (NDC 10139-0062-40). The 2-mL presentations are on back order and the company cannot estimate a release date.
• Parenta (Ebewe) has the 25 mg/mL 2-mL (NDC 66758-0040-02), 10-mL (NDC 66758-0040-08), and 40-mL vials (preservative free [NDC 66758-0041-01]) available.

Related Shortages

• Bleomycin Injection
• Carmustine Injection— Resolved
• Cisplatin Injection— Resolved
• Cyclophosphamide for Injection— Resolved
• Cyclophosphamide Tablets— Resolved
• Cytarabine Injection
• Doxorubicin Injection— Resolved
• Epirubicin Injection— Resolved
• Fluorouracil Injection— Resolved
• Hydroxyurea Capsules— Resolved
• Ifosfamide— Resolved
• Interferon Alfa Injection— No Longer Available
• Leuprolide Implant— No Longer Available
• Mechlorethamine Hydrochloride Injection— Resolved
• Melphalan Injection Injection— Resolved
• Mitomycin Injection
• Paclitaxel Injection— Resolved
• Procarbazine Capsules— Resolved
• Thiotepa Injection
• Vinblastine Injection
• Vincristine Injection— Resolved

Updated

October 27, 2009; September 22, 2009; September 2, 2009; August 18, 2009; August 5, 2009; June 30, 2009; June 3, 2009; June 1, 2009; May 15, 2009; May 12, 2009; April 21, 2009; April 7, 2009; October 16, 2008; September 24, 2008; July 1, 2008; May 12, 2008; April 3, 2008; February 28, 2008; December 19, 2007; November 14, 2007; October 2, 2007; September 4, 2007; August 9, 2007; July 25, 2007; July 3, 2007; June 14, 2007; May 4, 2007; April 19, 2007; March 26, 2007; February 27, 2007; January 25, 2007; October 23, 2006; August 30 and 9, 2006; June 22, 2006; April 27, 2006. University of Utah, Drug Information Service. Copyright 2009, Drug Information Service, University of Utah, Salt Lake City, UT.

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