Morphine Sulfate

16 April 2008

Products Affected - Description

Morphine sulfate extended-release oral tablets (MS Contin), Purdue Frederick
15 mg tablets, 120/package (NDC 00034-0514-12) - discontinued
30 mg tablets, 120/package (NDC 00034-0515-12) - discontinued
60 mg tablets, 120/package (NDC 00034-0516-12) - discontinued
100 mg tablets, 120/package (NDC 00034-0517-12) - discontinued
200 mg tablets, 120/package (NDC 00034-0513-12) - discontinued

Morphine sulfate immediate-release oral products (MSIR), Purdue Frederick
15 mg capsules, 100/package (NDC 00034-1025-10) - discontinued
15 mg tablets, 100/package (NDC 00034-0518-10) - discontinued
30 mg capsules, 100/package (NDC 00034-1026-10) - discontinued
30 mg caplets, 100/package (NDC 00034-0519-10) - discontinued
20 mg/mL liquid, 30 mL bottle (NDC 00034-0523-01) - discontinued
20 mg/mL liquid, 120 mL bottle (NDC 00034-0523-02) - discontinued

Morphine sulfate immediate-release soluble tablets, Ranbaxy
10 mg tablets, 100/package (NDC 63304-0706-01) - discontinued
15 mg tablets, 100/package (NDC 63304-0707-01) - discontinued
30 mg tablets, 100/package (NDC 63304-0708-01) - discontinued

Reason for the Shortage

Morphine sulfate extended-release oral products

• Morphine sulfate controlled-release oral tablets (MS Contin) in 15 mg, 30 mg, 60 mg, 100 mg, and 200 mg strengths from Purdue Frederick in the #120 package size have been discontinued.¹

• Purdue Frederick discontinued all morphine sulfate immediate-release oral products (MSIR).¹
• King Pharmaceuticals discontinued production of morphine immediate-release oral tablets and oral solution several years ago.²
• Ranbaxy discontinued immediate release soluble tablets in November 2007.³

Estimated Resupply Dates

Morphine sulfate extended-release oral products

• Purdue Frederick has morphine sulfate controlled-release oral tablets (MS Contin) available. The 120-count bottles were discontinued.¹
• Xanodyne has morphine sulfate sustained-release oral tablets (Oramorph SR) available.⁴
• King has morphine sulfate extended-release oral capsules (Avinza) available.²
• Alpharma has morphine sulfate extended-release oral capsules (Kadian) available.⁵
• Morphine sulfate extended-release oral tablets are available from Endo Generics and Mallinckrodt.^6,7
• Morphine sulfate controlled-release oral tablets are available from Watson in 15 mg, 30 mg, 60 mg, 100 mg, and 200 mg strengths.⁸

• Purdue Frederick discontinued morphine sulfate immediate-release oral products (MSIR).¹
• Ranbaxy discontinued morphine soluble tablets in 10 mg, 15 mg, and 30 mg tablets. ³
• Immediate-release oral morphine is available from Ethex in both solid and liquid dosage forms. ⁹
• Roxane has both their solid and liquid dosage forms of morphine sulfate immediate-release available. ¹⁰

Related Shortages

• Alfentanil Injection— Resolved
• Butorphanol Injection— Resolved
• Choline Magnesium Trisalicylate
• Codeine Phosphate Oral Solution— No Longer Available
• Diazepam Injection— Resolved
• Fentanyl Transdermal System Patch— Resolved
• Hydrocodone Tablets
• Hydromorphone Hydrochloride Injection
• Indomethacin Capsules— Resolved
• Meperidine— Resolved
• Meperidine / Promethazine— No Longer Available
• Methadone Hydrochloride Injection— Resolved
• Methadone Hydrochloride Tablets— Resolved
• Methadone Injection— Resolved
• Methadone Oral Tablets and Liquid— Resolved
• Morphine PCA Syringes— Resolved
• Morphine Sulfate: Extended-Release Products
• Morphine Sulfate: Oral Concentrated Solution
• Oxycodone Combinations Capsules and Tablets
• Oxycodone Extended-Release Tablets— Resolved
• Oxycodone Tablets, Capsules, and Solutions
• Pentazocine / Naloxone Tablets
• Remifentanil Hydrochloride— Resolved
• Sufentanil Injection— Resolved

1. Purdue Frederick, Customer Service (personal communication). April 16, 2008.
2. King Pharmaceuticals, Customer Service (personal communications). April 16, 2008.
3. Ranbaxy Pharmaceuticals, Customer Service (personal communication). February 18, 2008.
4. Xanodyne Pharmaceuticals, Inc., Customer Service (personal communication). April 16, 2008.
5. Alpharma, Customer Service (personal communications). April 16, 2008.
6. Endo Laboratories, Customer Service (personal communication). April 16, 2008.
7. Mallinckrodt (personal communication). October 31, 2006 and April 16, 2008.
8. Watson Laboratories, Customer Service (personal communication). April 16, 2008.
9. Ethex Corporation, Customer Service (personal communication). April 16, 2008.
10. Roxane Laboratories, Customer Service (personal communication). April 16, 2008.

Updated

Created April 16, 2008 by Jane Chandramouli, Pharm.D., Drug Information Specialist. Copyright 2008, Drug Information Service, University of Utah, Salt Lake City, UT.

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