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Piperacillin Tazobactam Injection

[29 April 2016]

Products Affected - Description

Zosyn solution for injection, Baxter
2.25 gram/50 mL frozen premix bag, 24 count (NDC 00206-8860-02)
3.375 gram/50 mL frozen premix bag, 24 count (NDC 00206-8861-02)
4.5 gram/50 mL frozen premix bag, 12 count (NDC 00206-8862-02)
 
Zosyn powder for solution for injection, Pfizer
2.25 gram vial, 10 count (NDC 00206-8852-16)
3.375 gram vial, 10 count (NDC 00206-8854-16)
4.5 gram vial, 10 count (NDC 00206-8855-16)
40.5 gram bulk vial, 1 single count (NDC 00206-8859-10) 
 
Piperacillin and Tazobactam powder for solution for injection, Apotex
2.25 gram vial, 10 count (NDC 60505-0686-04)
3.375 gram vial, 10 count (NDC 60505-0687-04)
4.5 gram vial, 10 count (NDC 60505-0688-04)
40.5 gram bulk vial, 1 count (NDC 60505-0773-00)

Piperacillin and Tazobactam powder for solution for injection, AuroMedics
2.25 gram vial, 10 count (NDC 55150-0119-30)
3.375 gram vial, 10 count (NDC 55150-0120-30)
4.5 gram vial, 10 count (NDC 55150-0121-50)
 
Piperacillin and Tazobactam powder for solution for injection, Fresenius Kabi
2.25 gram vial, 10 count (NDC 63323-0309-20)
3.375 gram vial, 10 count (NDC 63323-0300-30)
4.5 gram vial, 10 count (NDC 63323-0320-50)
40.5 gram bulk vial, 1 count (NDC 63323-0304-74)

Piperacillin and Tazobactam powder for solution for injection, Hospira
2.25 gram, vial, 10 count (NDC 00409-3383-02)
2.25 gram, ADD-Vantage vial, 10 count (NDC 00409-3374-02)
3.375 gram, vial, 10 count (NDC 00409-3385-13)
3.375 gram, ADD-Vantage vial, 10 count (NDC 00409-3378-13)
 4.5 gram ADD-Vantage vial, 10 count (NDC 00409-3379-04)
4.5 gram vial, 10 count (NDC 00409-3390-04)
 
Piperacillin and Tazobactam powder for solution for injection, Sagent
2.25 gram vial, 10 count (NDC 25021-0164-30)
3.375 gram vial, 10 count (NDC 25021-0165-30)
4.5 gram vial, 10 count (NDC 25021-0166-48)
 
Piperacillin/Tazobactam powder for solution for injection, Sandoz
2.25 gram vial, 10 count (NDC 00781-3110-95) - discontinued
3.375 gram vial, 10 count (NDC 00781-3113-95) - discontinued
4.5 gram vial, 10 count (NDC 00781-3114-95) - discontinued
 
Piperacillin and Tazobactam powder for solution for injection, WG Critical Care
2.25 gram vial, 10 count (NDC 44567-0801-10)
3.375 gram vial, 10 count (NDC 44567-0802-10)
4.5 gram vial, 10 count (NDC 44567-0803-10)
40.5 gram, bulk vial, 1 count (NDC 44567-0804-01)

Reason for the Shortage

  • Apotex has piperacillin/tazobactam on shortage due to regulatory delays.
  • AuroMedics and Sandoz could not provide a reason for the shortage.
  • Baxter has Zosyn frozen premixes on allocation due to increased demand.
  • Fresenius Kabi has piperacillin/tazobactam on shortage due to increased demand.
  • Sagent has piperacillin/tazobactam on shortage due to increased demand.
  • Pfizer has Zosyn on shortage due to manufacturing delays. Pfizer estimates there will be supply shortages through December 2015 for the single dose vials and 1st quarter 2017 for the bulk vials.
  • Sandoz discontinued piperacillin/tazobactam in late 2015.
  • WG Critical Care states the reason for the shortage is increased demand.

Available Products

Insufficient supplies for usual ordering.

Estimated Resupply Dates

  • Apotex has all piperacillin/tazobactam presentations on back order and the company estimates a release date of early-May 2016.
  • AuroMedics has piperacillin/tazobactam on intermittent back order and the company is releasing product as it becomes available. Check wholesalers for inventory.
  • Baxter has all Zosyn frozen premixes available on allocation.
  • Fresenius Kabi has piperacillin/tazobactam 2.25 gram and 3.375 gram vials on back order and the company estimates a release date of early-May 2016. Piperacillin/tazobactam 4.5 gram, and 40.5 gram vials are on back order and the company estimates a release date of mid-May 2016 for the 4.5 gram vials and mid-June 2016 for the 40.5 gram vials.
  • Hospira has piperacillin/tazobactam 2.25 gram vials on back order and the company estimates a release date of late-May 2016. The 2.25 gram ADD-Vantage vials, 3.375 gram vials, 3.375 gram ADD-Vantage vials, 4.5 gram ADD-Vantage vials, and 4.5 gram vials are available in limited supply.
  • Pfizer has Zosyn 2.25 gram vials, 3.375 gram vials, and 4.5 gram vials on back order and the company estimates a release date of January 2017. The 40.5 gram bulk vials have an estimated release date of 3rd quarter 2017.
  • Sagent has piperacillin/tazobactam 2.25 gram, 3.375 gram, and 4.5 gram vials on back order and the company estimates a release date of May 2016.
  • WG Critical Care has all piperacillin/tazobactam presentations on back order and the company cannot estimate a release date.

Related Shortages

Updated

April 29, 25 and 6, March 7 and 1, February 26 and 4, January 6, 2016; December 22 and 17, November 20, 9 and 3, October 19, 12 and 6, September 14 and 3, August 6, July 14, June 5, May 27 and 11, April 30, 16 and 10, March 25, 13 and 3, February 25, January 26 and 9, 2015; December 22, 18, 16 and 3, November 25, 17 and 7, October 24 and 8, September 22 and 3, August 19, 7 and 6, July 17 and 2, May 14 and 5, April 23, March 31, 28, 12 and 5, 2014, University of Utah, Drug Information Service. Copyright 2016, Drug Information Service, University of Utah, Salt Lake City, UT.

Disclaimer

This information is provided through the support of Novation to ASHP solely as a service to its members, which shall not use this information for their further commercial use. The content was prepared by the Drug Information Center of University of Utah. Novation, ASHP, and the University of Utah make no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, which respect to such information, and specifically disclaim all such warranties. Users of this information are advised that decisions regarding the use of drugs and drug therapies are complex medical decisions and that in using this information, each user must exercise his or her own independent professional judgment. Neither Novation, ASHP nor the University of Utah assumes any liability for persons administering or receiving drugs or other medical care in reliance upon this information, or otherwise in connection with this bulletin. Neither Novation, ASHP nor University of Utah endorses or recommends the use of any drug.

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