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Morphine Injections

[01 December 2014]

Products Affected - Description

Astramorph (preservative-free) injection, Fresenius Kabi
0.5 mg/mL 2 mL ampule, 10 count (NDC 63323-0291-80)
0.5 mg/mL 10 mL vial, 5 count (NDC 63323-0291-10)
0.5 mg/mL 10 mL ampule (NDC 63323-0291-97)
1 mg/mL 2 mL ampule, 10 count (NDC 63323-0292-80)
1 mg/mL, 10 mL vial (NDC 63323-0292-10)
1 mg/mL 10 mL ampule (NDC 63323-0292-97)
 
Morphine injection, Hospira
1 mg/mL 10 mL preservative-free vial (NDC 00409-3815-12)
25 mg/mL, 10 mL Add-Vantage vial (NDC 00409-6179-14)
 
Infumorph (preservative-free), West-Ward
25 mg/mL, 20 mL ampule (NDC 00641-6040-01)

Reason for the Shortage

  • Fresenius Kabi (formerly APP) states the shortage is due to a change in manufacturing sites.
  • Hospira states the shortage is due to manufacturing delays.
  • Hospira discontinued preservative-containing Carpuject syringes in August, 2012 and replaced them with preservative-free Carpuject syringes.
  • West-Ward states the shortage was due to increased demand for product. West-Ward changed old Baxter to new West-Ward NDC codes in early 2012.
  • IMS (Amphastar) discontinued morphine 1 mg/mL 10 mL Luer-lock syringes in March, 2012 due to low demand for the product.

Available Products

Morphine Injection, BD Rx
2 mg/mL, 1 mL preservative-free syringe (NDC 76045-0004-10)
4 mg/mL, 1 mL preservative-free syringe (NDC 76045-0005-10)
5 mg/mL, 1 mL preservative-free syringe (NDC 76045-0006-10)
8 mg/mL, 1 mL preservative-free syringe (NDC 76045-0007-10)
10 mg/mL, 1 mL preservative-free syringe (NDC 76045-0008-10)
 
Morphine Injection, Hospira
0.5 mg/mL 10 mL, preservative-free vial (NDC 00409-3814-12)
2 mg/mL, 1 mL preservative-free Carpuject syringe (NDC 00409-1890-01)
2 mg/mL, 1 mL preservative-free iSecure syringe (NDC 00409-1890-11)
4 mg/mL, 1 mL preservative-free Carpuject syringe (NDC 00409-1891-01)
4 mg/mL, 1 mL preservative-free iSecure syringe (NDC 00409-1891-11)
8 mg/mL, 1 mL preservative-free Carpuject syringe (NDC 00409-1892-01)
10 mg/mL, 1 mL preservative-free Carpuject syringe (NDC 00409-1893-01)
15 mg/mL, 1 mL preservative-free Carpuject syringe (NDC 00409-1894-01)
1 mg/mL, 30 mL PCA vial (NDC 00409-2029-02)
5 mg/mL, 30 mL PCA vial (NDC 00409-6028-04)
25 mg/mL, 1 mL preservative-free vial (NDC 00409-1135-02)
25 mg/mL 4 mL Add-Vantage vial (NDC 00409-6177-14)
50 mg/mL, 20 mL vial (NDC 00409-1134-03)
50 mg/mL, 50 mL vial (NDC 00409-1134-05)
 
Morphine injection, West-Ward
5 mg/mL, 1 mL vial (NDC 00641-6073-25)
8 mg/mL, 1 mL vial (NDC 00641-6075-25)
10 mg/mL, 1 mL vial (NDC 00641-6070-25)
10 mg/mL, 10 mL vial (NDC 00641-6068-01)
15 mg/mL, 1 mL vial (NDC 00641-6071-25)
15 mg/mL, 20 mL vial (NDC 00641-6072-01)
 
Duramorph (preservative-free), West-Ward
0.5 mg/mL, 10 mL ampules (NDC 00641-6020-10)
1 mg/mL, 10 mL ampules (NDC 00641-6019-10)
 
Infumorph (preservative-free), West-Ward
10 mg/mL, 20 mL ampule (NDC 00641-6039-01)

Estimated Resupply Dates

  • Fresenius Kabi has all preservative-free Astramorph presentations on long-term back order and the company cannot estimate a release date.
  • Hospira has morphine 1 mg/mL 10 mL preservative-free vials on back order and the company estimates a release date of mid-December 2014. Morphine 25 mg/mL 10 mL ADD-Vantage vials are on back order and the company cannot estimate a release date.
  • West-Ward has Infumorph 25 mg/mL 20 mL ampules available but the product has short expiration dating (November 2015). West-Ward has morphine 10 mg/mL 1 mL vials, 8 mg/mL 1 mL vials, and 15 mg/mL 1 mL vials available with good dating and short expiration dating (April 2015).

Related Shortages

Updated

December 1, 2014; November 14, 2014; November 10, 2014; October 31, 2014; October 17, 2014; September 23, 2014; August 29, 2014; July 30, 2014; July 14, 2014; June 12, 2014; May 19, 2014; April 23, 2014; March 31, 2014; February 14, 2014; December 10, 2013; November 1, 2013; October 11, 2013; September 3, 2013; August 14, 2013; July 12, 2013; June 19, 2013; April 25, 2013; March 21, 2013; February 6, 2013; January 9, 2013; December 12, 2012; November 9, 2012; October 24, 2012; September 18, 2012; June 15, 2012; May 25, 2012; April 4, 2012; March 21, 2012; February 23, 2012; January 24, 2012; December 22, 2011; November 21, 2011; October 11, 2011; September 29, 2011; August 19, 2011; July 14, 2011; June 23, 2011; May 5, 2011; March 24, 2011; February 15, 2011; January 6, 2011, University of Utah, Drug Information Service. Copyright 2014, Drug Information Service, University of Utah, Salt Lake City, UT.

Disclaimer

This information is provided through the support of Novation to ASHP solely as a service to its members, which shall not use this information for their further commercial use. The content was prepared by the Drug Information Center of University of Utah. Novation, ASHP, and the University of Utah make no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, which respect to such information, and specifically disclaim all such warranties. Users of this information are advised that decisions regarding the use of drugs and drug therapies are complex medical decisions and that in using this information, each user must exercise his or her own independent professional judgment. Neither Novation, ASHP nor the University of Utah assumes any liability for persons administering or receiving drugs or other medical care in reliance upon this information, or otherwise in connection with this bulletin. Neither Novation, ASHP nor University of Utah endorses or recommends the use of any drug.

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