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Epinephrine Injection

[19 March 2015]

Products Affected - Description

Epinephrine injection, American Regent
1 mg/mL, 1 mL ampule, sulfite-free and preservative-free, package of 25, (NDC 00517-1071-25) - discontinued
1 mg/mL, 30 mL multi-dose vial, package of 5 (NDC 00517-1130-05) - discontinued
 
Epinephrine injection, Amphastar
0.1 mg/mL 10 mL syringe, package of 10 (NDC 76329-3316-01)
1 mg/mL, 30 mL vial (NDC 76329-9061-00)

Epinephrine injection, Hospira
0.1 mg/mL, 10 mL Lifeshield 20 gauge glass syringe, package of 10 (NDC 00409-4921-34)
0.1 mg/mL, 10 mL Abboject18 gauge glass syringe, package of 10 (NDC 00409-4901-18)

Reason for the Shortage

  • American Regent discontinued both epinephrine presentations in early-2015.
  • Amphastar states the shortage is due to increased demand.
  • BPI Labs received FDA approval for epinephrine injection in 2014 and the company launched product in February 2015.
  • Hospira has epinephrine syringes on shortage due to manufacturing delays.

Available Products

Epinephrine injection, BPI Labs
1 mg/mL, 2 mL ampule containing 1 mL solution, sulfite-free and preservative-free, package of 10 (NDC 54288-0103-10)
 
Epinephrine injection, Hospira
1 mg/mL, 1 mL ampule, preservative-free (contains sulfite), package of 25, (NDC 00409-7241-01)
 
Adrenalin injection, Par Pharmaceuticals (formerly JHP products)
1 mg/mL, 1 mL vial, preservative-free (contains sulfite), package of 25 (NDC 42023-0159-25)
 

Estimated Resupply Dates

  • American Regent has discontinued epinephrine 1 mg/mL 30 mL vials and epinephrine 1 mg/mL preservative free (sulfite-free) 1 mL ampules.
  • Amphastar has epinephrine 1 mg/mL 30 mL vials and epinephrine 0.1 mg/mL 10 mL syringes on intermittent back order and the company is releasing product regularly.
  • Hospira has 0.1 mg/mL 10 mL 20 gauge Lifeshield syringes available in limited supply. The 0.1 mg/mL 10 mL 18 gauge Abboject syringes are on back order and the company estimates a release date of early-April 2015.

Related Shortages

Updated

March 19, February 13, 2015; December 15, November 20 and 21, October 8, August 6 and 26, June 11, April 3 and 30, March 7, February 19, January 16, 2014; December 13, October 15 and 16, September 16, August 13, July 1, June 19, May 9 and 30, April 8 and 26, March 18 and 21, February 6 and 26, January 14 and 23, 2013; December 3, 18, and 26, November 7 and 30, October 26, September 25, August 1 and 17, July 25, June 15 and 28, May 2 and 18, March 9 and 27, February 8 and 23, January 13, 17, and 25, 2012; November 15, September 14, August 9, July 15, June 13; May 3 and 4, 2011; University of Utah, Drug Information Service. Copyright 2015, University of Utah, Drug Information Service.

Disclaimer

This information is provided through the support of Novation to ASHP solely as a service to its members, which shall not use this information for their further commercial use. The content was prepared by the Drug Information Center of University of Utah. Novation, ASHP, and the University of Utah make no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, which respect to such information, and specifically disclaim all such warranties. Users of this information are advised that decisions regarding the use of drugs and drug therapies are complex medical decisions and that in using this information, each user must exercise his or her own independent professional judgment. Neither Novation, ASHP nor the University of Utah assumes any liability for persons administering or receiving drugs or other medical care in reliance upon this information, or otherwise in connection with this bulletin. Neither Novation, ASHP nor University of Utah endorses or recommends the use of any drug.

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