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Diphtheria, Tetanus Toxoid, and Acellular Pertussis Vaccine (DTaP)

[18 November 2016]

Products Affected - Description

All presentations are currently available

Reason for the Shortage

  • Sanofi Pasteur had Daptacel in short supply due to the shortage of other combination vaccines (eg, Pentacel).1,2
  • GlaxoSmithKline has Infanrix available.3

Available Products

Daptacel vaccine, Sanofi Pasteur
0.5 mL, single dose vial, 10 count (NDC 49281-0286-10)
 
Infanrix vaccine, GlaxoSmithKline Vaccines
0.5 mL, single dose vial, 10 count (NDC 58160-0810-11)
0.5 mL, syringe, 10 count (NDC 58160-0810-52)

Estimated Resupply Dates

Sanofi Pasteur has Daptacel vaccine readily available.1

Implications for Patient Care

Daptacel is labeled for active immunization against tetanus, diphtheria, and pertussis (DTaP) as a 5-dose series in pediatric patients ages 6 weeks to 6 years old.4

Safety

Ensure patients receive the adequate number of vaccinations as outlined by the Centers for Disease Control and Prevention (CDC) Recommended Immunization Schedules.5,6

Alternative Agents & Management

The CDC has a guidance document available for clinicians during the shortage of Pentacel vaccine.7

Related Shortages

References

  1. Sanofi Pasteur (personal communications). January 14, February 3 and 17, March 22, April 26, June 16, July 20, September 6, October 17, and November 17, 2016.
  2. Sanofi Pasteur. Dear Health Care Provider Letter (December 2015). Accessed January 14, 2016.
  3. GlaxoSmithKline (personal communications). January 14, February 3 and 17, and March 22, 2016.
  4. Sanofi Pasteur. Daptacel (Diphtheria and Tetanus Toxoids and Acellular Pertussis Adsorbed) Suspension for Intramuscular Injection [product labeling]. Swiftwater, PA: Sanofi Pasteur; 2013.
  5. Centers for Disease Control and Prevention (CDC). General Recommendations on Immunization, Recommendations of the Advisory Committee on Immunization Practice. MMWR Morb Mortal Wkly Rep. 2011 Jan 28;60(RR02):1-60. Accessed January 14, 2016.
  6. Department of Health and Human Services, Centers for Disease Control and Prevention. Recommended Immunization Schedule for Persons Ages 0 to 18 Years, United States 2015. Accessed January 14, 2016.
  7. Department of Health and Human Services, Centers for Disease Control and Prevention. Guidance for vaccinating children during the 2015-16 Pentacel manufacturing delay. Accessed January 14, 2016.

Updated

Updated November 18, 2016, by Elyse MacDonald, PharmD, MS, BCPS. Created February 17, 2016 by Jane Chandramouli, PharmD, Drug Information Specialist. Copyright 2016, Drug Information Service, University of Utah, Salt Lake City, UT.

Disclaimer

This information is provided through the support of Vizient to ASHP solely as a service to its members, which shall not use this information for their further commercial use. The content was prepared by the Drug Information Center of University of Utah. Vizient, ASHP, and the University of Utah make no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, which respect to such information, and specifically disclaim all such warranties. Users of this information are advised that decisions regarding the use of drugs and drug therapies are complex medical decisions and that in using this information, each user must exercise his or her own independent professional judgment. Neither Vizient, ASHP nor the University of Utah assumes any liability for persons administering or receiving drugs or other medical care in reliance upon this information, or otherwise in connection with this bulletin. Neither Vizient, ASHP nor University of Utah endorses or recommends the use of any drug.

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