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Methylprednisolone Acetate Injection

[04 August 2015]

Products Affected - Description

Methylprednisolone acetate injection, Sandoz
40 mg/mL, 1 mL vials, 1 count (NDC 00781-3131-71)
40 mg/mL, 1 mL vials, 10 count (NDC 00781-3131-95)
40 mg/mL, 10 mL vials, 1 count (NDC 00781-3136-70)
80 mg/mL, 1 mL vials, 1 count (NDC 00781-3132-71)
80 mg/mL, 1 mL vials, 10 count (NDC 00781-3132-95)
80 mg/mL, 5 mL vials, 1 count (NDC 00781-3137-75)
 
Methylprednisolone acetate injection, Teva
40 mg/mL, 1 mL vials, 1 count (NDC 00703-0031-01)
40 mg/mL, 1 mL vials, 25 count (NDC 00703-0031-04)
40 mg/mL, 5 mL vials, 1 count (NDC 00703-0043-01)
40 mg/mL, 10 mL vials, 1 count (NDC 00703-0045-01)
80 mg/mL, 1 mL vials, 1 count (NDC 00703-0051-01)
80 mg/mL, 1 mL vials, 25 count (NDC 00703-0051-04)
80 mg/mL, 5 mL vials, 1 count (NDC 00703-0063-01)

Reason for the Shortage

  • Sandoz and Teva could not provide a reason for the shortage.
  • Pfizer has Depo-Medrol injection available and is supplying the market.

Available Products

Depo-Medrol injection, Pfizer
20 mg/mL, 5 mL vials, 1 count (NDC 00009-0274-01)
40 mg/mL, 1 mL vials, 1 count (NDC 00009-3073-01)
40 mg/mL, 1 mL vials, 25 count (NDC 00009-3073-03)
40 mg/mL, 5 mL vials, 1 count (NDC 00009-0280-02)
40 mg/mL, 5 mL vials, 25 count (NDC 00009-0280-51)
40 mg/mL, 10 mL vials, 1 count (NDC 00009-0280-03)
40 mg/mL, 10 mL vials, 25 count (NDC 00009-0280-52)
80 mg/mL, 1 mL vials, 1 count (NDC 00009-3475-01)
80 mg/mL, 1 mL vials, 25 count (NDC 00009-3475-03)
80 mg/mL 5 mL vials, 1 count (NDC 00009-0306-02)
80 mg/mL 5 mL vials, 25 count (NDC 00009-0306-12)

Estimated Resupply Dates

  • Sandoz has methylprednisolone acetate injection on long-term back order and the company cannot estimate a release date.
  • Teva has all methylprednisolone acetate presentations on long-term back order and the company cannot estimate a release date.

Implications for Patient Care

  • FDA closed New England Compounding Company in Massachusetts due to a fungal meningitis outbreak linked to methylprednisolone acetate injections compounded by this pharmacy.
  • All commercially available products contain a preservative such as myristyl gamma picolinium chloride or benzyl alcohol.
  • Methylprednisolone acetate is not approved for epidural administration and contraindicated for intrathecal use.

Related Shortages

Updated

August 4, June 15, April 7 and 30, March 4 and 20, February 2, January 9, 2015; December 12, October 10 and 21, September 5 and 22, August 13 and 28, July 21 and 31, June 19 and 30, April 24, March 11 and 17, February 3, January 15, 2014; November 14, September 26, August 6 and 22, July 16 and 23, May 3, April 19, March 15, January 22, 2013; November 16 and 20, October 5, September 26, August 21, July 9 and 26, June 20, May 22, 2012, University of Utah, Drug Information Service. Copyright 2015, Drug Information Service, University of Utah, Salt Lake City, UT.

Disclaimer

This information is provided through the support of Novation to ASHP solely as a service to its members, which shall not use this information for their further commercial use. The content was prepared by the Drug Information Center of University of Utah. Novation, ASHP, and the University of Utah make no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, which respect to such information, and specifically disclaim all such warranties. Users of this information are advised that decisions regarding the use of drugs and drug therapies are complex medical decisions and that in using this information, each user must exercise his or her own independent professional judgment. Neither Novation, ASHP nor the University of Utah assumes any liability for persons administering or receiving drugs or other medical care in reliance upon this information, or otherwise in connection with this bulletin. Neither Novation, ASHP nor University of Utah endorses or recommends the use of any drug.

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