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Bupivacaine with epinephrine Injection

[16 July 2014]

Products Affected - Description

Bupivacaine 0.25% with epinephrine
Bupivacaine 0.25% with epinephrine 1:200,000 injection, Hospira
10 mL vial, preservative-free (NDC 00409-9042-01)
30 mL vial, preservative-free (NDC 00409-9042-17)
 
Marcaine 0.25% (with epinephrine 1:200,000) injection, Hospira
10 mL vial, preservative-free (NDC 00409-1746-10)
30 mL vial, preservative-free (NDC 00409-1746-30)
50 mL vial, multi-dose (NDC 00409-1752-50)
 
Sensorcaine 0.25% (with epinephrine 1:200,000), Fresenius Kabi
10 mL vial, preservative-free (NDC 63323-0468-17)
30 mL vial, preservative-free (NDC 63323-0468-37)
50 mL vial, multi-dose (NDC 63323-0461-57)
 
Bupivacaine 0.5% with epinephrine
Bupivacaine 0.5% with epinephrine 1:200,000 injection, Hospira
10 mL vial, preservative-free (NDC 00409-9045-01)
50 mL vial, multi-dose (NDC 00409-9046-01)

Marcaine 0.5% with epinephrine 1:200,000 injection, Hospira
10 mL vial, preservative-free (NDC 00409-1749-10)
30 mL vial, preservative-free (NDC 00409-1749-29)
50 mL vial, multi-dose (NDC 00409-1755-50)

Sensorcaine 0.5% with epinephrine 1:200,000, Fresenius Kabi
50 mL vial, multi-dose (NDC 63323-0463-57)   
 
Bupivacaine 0.75% with epinephrine
Sensorcaine 0.75% with epinephrine1:200,000, Fresenius Kabi
30 mL vial, preservative-free (NDC 63323-0460-37)

Reason for the Shortage

  • Fresenius Kabi (formerly APP) has Sensorcaine with epinephrine on shortage due to increased demand for the product. 
  • Hospira has bupivacaine with epinephrine and Marcaine with epinephrine on shortage due to manufacturing delays.

Available Products

Bupivacaine 0.25% with epinephrine
Bupivacaine 0.25% with epinephrine 1:200,000 injection, Hospira
50 mL vial, multi-dose (NDC 00409-9043-01)

Bupivacaine 0.5% with epinephrine

Sensorcaine 0.5% with epinephrine 1:200,000, Fresenius Kabi
10 mL vial, preservative-free (NDC 63323-0462-17)
30 mL vial, preservative-free (NDC 63323-0462-37)
30 mL vial, preservative-free, sterile pack (NDC 63323-0462-31)
 
Bupivacaine 0.5% with epinephrine 1:200,000 injection, Hospira
30 mL vial, preservative-free (NDC 00409-9045-17)

Bupivacaine 0.75% with epinephrine

There are insufficient supplies for usual ordering.

Estimated Resupply Dates

Bupivacaine 0.25% with epinephrine
  • Fresenius Kabi has Sensorcaine 0.25% with epinephrine 10 mL and 30 mL preservative-free vials and 50 mL multi-dose vials on intermittent back order with regular releases.
  • Hospira has bupivacaine 0.25% with epinephrine 10 mL and 30 mL preservative-free vials on back order and the company estimates a release date of July 2014.
  • Hospira has Marcaine 0.25% with epinephrine 10 mL and 30 mL preservative-free vials available in limited supply. Marcaine 0.25% with epinephrine 50 mL multi-dose vials are on back order with an estimated release date of July 2014.

Bupivacaine 0.5% with epinephrine

  • Hospira has bupivacaine 0.5% with epinephrine 50 mL multi-dose vials on back order and the company estimates a release date of July 2014. Bupivacaine 0.5% with epinephrine 10 mL preservative-free vials are on back order and the company estimates a release date of August 2014.
  • Hospira has Marcaine 0.5% with epinephrine 10 mL and 30 mL preservative-free vials available in limited supply. Marcaine 0.5% with epinephrine 50 mL vials are on back order with an estimated release date of July 2014.
  • Fresenius Kabi has Sensorcaine 0.5% with epinephrine 50 mL multi-dose vials on back order and the company estimates a release date of September 2014.

Bupivacaine 0.75% with epinephrine

  • Fresenius Kabi has Sensorcaine 0.75% with epinephrine 30 mL preservative-free vials on allocation with short expiration dates of 5 or 6 months.

Related Shortages

Updated

July 16, 2014; June 11, 2014; June 2, 2014; May 12, 2014; May 1, 2014; April 16, 2014; March 27, 2014; March 14, 2014; March 6, 2014; February 27, 2014; January 21, 2014; January 3, 2014; December 27, 2013; December 3, 2013; November 19, 2013; November 5, 2013; October 7, 2013; September 25, 2013; September 18, 2013; August 28, 2013; July 12, 2013; June 24, 2013; May 22, 2013; April 29, 2013; March 29, 2013; February 22, 2013; January 2, 2013; December 18, 2012; November 28, 2012; October 22, 2012; September 24, 2012; August 22, 2012; July 25, 2012; June 5, 2012; May 17, 2012; April 16, 2012; March 27, 2012; February 8, 2012; January 25, 2012; December 21, 2011; November 16, 2011; October 27, 2011; September 21, 2011; August 24, 2011; July 28, 2011; June 30 2011; May 23, 2011; April 7, 2011; March 24, 2011; University of Utah, Drug Information Service. Copyright 2014, Drug Information Service, University of Utah, Salt Lake City, UT.

Disclaimer

This information is provided through the support of Novation to ASHP solely as a service to its members, which shall not use this information for their further commercial use. The content was prepared by the Drug Information Center of University of Utah. Novation, ASHP, and the University of Utah make no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, which respect to such information, and specifically disclaim all such warranties. Users of this information are advised that decisions regarding the use of drugs and drug therapies are complex medical decisions and that in using this information, each user must exercise his or her own independent professional judgment. Neither Novation, ASHP nor the University of Utah assumes any liability for persons administering or receiving drugs or other medical care in reliance upon this information, or otherwise in connection with this bulletin. Neither Novation, ASHP nor University of Utah endorses or recommends the use of any drug.

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