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Yellow Fever Vaccine

Products Affected - Description

    • YF-Vax subcutaneous powder for suspension for injection, Sanofi Pasteur, Multiple-dose vial (5 doses per vial) with diluent 1 count, NDC 49281-0915-05
    • YF-Vax subcutaneous powder for suspension for injection, Sanofi Pasteur, Single-dose vial with diluent, 5 count, NDC 49281-0915-01

Reason for the Shortage

    • Sanofi Pasteur states the shortage of YF-Vax is due to production delays. [1]
    • There are no other suppliers of yellow fever vaccine.
    • Additional information on the yellow fever shortage is available at

Available Products

    • There are no presentations available

Estimated Resupply Dates

    • Sanofi Pasteur has YF-Vax multi-dose vials and single dose vials on back order and the company does not expect product to return to market in 2019. The company will release additional information regarding YF-Vax availability in 4th quarter 2019.[1]
    • FDA accepted an investigational new drug application in October 2016. This is for the importation of another yellow fever vaccine from France. The trade name of the imported product is Stamaril. The product information can be found at The initial rollout began in April 2017. More information can be found at or at
    • Stamari is on allocation due to supply demand.[1]

Implications for Patient Care

    • Yellow fever vaccine must be used within 1 hour of reconstitution. Practitioners should consider scheduling several patients for immunization simultaneously to conserve use of YF-Vax 5-dose vials.[2]

Alternative Agents & Management

    • Information on countries that require yellow fever vaccination can be found at


    1. Sanofi Pasteur, Customer Service (personal communication and website). November 24 and December 15, 2015; January 13, February 3, March 22, April 18, May 31, July 20, September 27, and November 29, 2016; January 31, March 27, June 27, August 29, November 1, December 15, 2017; February 7, April 11, June 11, August 1, October 25, 2018; and January 30, April 15 and 26, July 9, October 9, and November 11, 2019.
    2. Yellow Fever Vaccine (YF-Vax). Product information. Swiftwater, PA: Sanofi Pasteur, 2014 March.


Updated November 11, 2019 by Stephen Andrews, PharmD, BCPS, Drug Information Specialist. Created November 24, 2015 by Leslie Jensen, PharmD, Drug Information Specialist. © 2019, Drug Information Service, University of Utah, Salt Lake City, UT.


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