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Asparaginase Erwinia chrysanthemi

Products Affected - Description

    • Erwinaze lyophilized powder for injection, Jazz Pharmaceuticals, 10,000 unit, vial, 1 count, NDC 57902-0249-01
    • Erwinaze lyophilized powder for injection, Jazz Pharmaceuticals, 10,000 unit, vial, 5 count, NDC 57902-0249-05

Reason for the Shortage

    • Erwinaze supply disruption is due to ongoing manufacturing issues and capacity constraints at Porton Biopharma Limited, the sole manufacturer of Erwinaze. Erwinaze is distributed by Jazz Pharmaceuticals. After the batch released in May 2021, Clinigen will be the new distributor instead of Jazz.

Available Products

    • There is insufficient supply for usual ordering

Estimated Resupply Dates

    • Jazz Pharmaceuticals has Erwinaze 10,000 unit vials in 1 count and 5 count available in limited supply. After this batch released in May 2021, Erwinaze will be distributed by Clinigen instead of Jazz.


    • Jazz Pharmaceuticals sent Dear Health Care Provider letters regarding the administration of certain batches of Erwinaze. Particulate matter was seen in vials from these batches during routine inspections. Use 5-micron filter needles when withdrawing Erwinaze from vials and use a 0.2 micron, low protein binding, in-line filter attached to the primary IV tubing for administration. See for additional details.


Updated May 10, 2021 by Michelle Wheeler, PharmD, Drug Information Specialist. Created October 11, 2018 by Michelle Wheeler, PharmD, Drug Information Specialist. © 2021, Drug Information Service, University of Utah, Salt Lake City, UT.



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