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7/9/2019

Piperacillin and Tazobactam Injection

Products Affected - Description

    • Zosyn powder for solution for injection, Pfizer, 2.25 gram, vial, 10 count, NDC 00206-8852-16
    • Zosyn powder for solution for injection, Pfizer, 3.375 gram, vial, 10 count, NDC 00206-8854-16
    • Zosyn powder for solution for injection, Pfizer, 4.5 gram, vial, 10 count, NDC 00206-8855-16
    • Zosyn powder for solution for injection, Pfizer, 40.5 gram, bulk vial, 1 count, NDC 00206-8859-10
    • Piperacillin and Tazobactam powder for solution for injection, AuroMedics, 3.375 gram, vial, 10 count, NDC 55150-0120-30
    • Piperacillin and Tazobactam powder for solution for injection, Pfizer, 2.25 gram, ADD-Vantage vial, 10 count, NDC 00409-3374-02

Reason for the Shortage

    • Apotex has piperacillin/tazobactam injection available.
    • Athenex has piperacillin/tazobactam injection available.
    • AuroMedics did not provide a reason for the shortage.
    • Baxter has piperacillin/tazobactam injection available.
    • Fresenius Kabi has piperacillin/tazobactam injection available.
    • Mylan Institutional refuses to provide updated availability information.
    • Pfizer has Zosyn single dose vials and piperacillin/tazobactam on shortage due to manufacturing delays.
    • Sagent has piperacillin/tazobactam injection on shortage due to increased demand.
    • Sandoz has piperacillin/tazobactam injection available.
    • WG Critical Care has piperacillin/tazobactam injection available.
    • Wockhardt has piperacillin/tazobactam injection available.
    • X-Gen has piperacillin/tazobactam injection available.

Available Products

    • Zosyn solution for injection, Baxter, 2.25 gram, 50 mL frozen premixed bag, 24 count, NDC 00206-8860-02
    • Zosyn solution for injection, Baxter, 3.375 gram, 50 mL frozen premixed bag, 24 count, NDC 00206-8861-02
    • Zosyn solution for injection, Baxter, 4.5 gram, 50 mL frozen premixed bag, 12 count, NDC 00206-8862-02
    • Piperacillin and Tazobactam powder for solution for injection, Apotex, 2.25 gram, vial, 10 count, NDC 60505-6156-04
    • Piperacillin and Tazobactam powder for solution for injection, Apotex, 3.375 gram, vial, 10 count, NDC 60505-6157-04
    • Piperacillin and Tazobactam powder for solution for injection, Apotex, 4.5 gram, vial, 10 count, NDC 60505-6159-04
    • Piperacillin and Tazobactam powder for solution for injection, Athenex, 2.25 gram, vial, 10 count, NDC 70860-0120-20
    • Piperacillin and Tazobactam powder for solution for injection, Athenex, 3.375 gram, vial, 10 count, NDC 70860-0121-30
    • Piperacillin and Tazobactam powder for solution for injection, Athenex, 4.5 gram, vial, 10 count, NDC 70860-0122-50
    • Piperacillin and Tazobactam powder for solution for injection, Athenex, 40.5 gram, vial, 1 count, NDC 70860-0123-99
    • Piperacillin and Tazobactam powder for solution for injection, AuroMedics, 2.25 gram, vial, 10 count, NDC 55150-0119-30
    • Piperacillin and Tazobactam powder for solution for injection, AuroMedics, 4.5 gram, vial, 10 count, NDC 55150-0121-50
    • Piperacillin and Tazobactam powder for solution for injection, Fresenius Kabi, 2.25 gram, vial, 10 count, NDC 63323-0309-20
    • Piperacillin and Tazobactam powder for solution for injection, Fresenius Kabi, 3.375 gram, vial, 10 count, NDC 63323-0300-30
    • Piperacillin and Tazobactam powder for solution for injection, Fresenius Kabi, 4.5 gram, vial, 10 count, NDC 63323-0320-50
    • Piperacillin and Tazobactam powder for solution for injection, Fresenius Kabi, 40.5 gram, bulk vial, 1 count, NDC 63323-0304-74
    • Piperacillin and Tazobactam powder for solution for injection, Pfizer, 13.5 gram, vial, 1 count, NDC 00409-2999-14
    • Piperacillin and Tazobactam powder for solution for injection, Pfizer, 2.25 gram, vial, 10 count, NDC 00409-3383-02
    • Piperacillin and Tazobactam powder for solution for injection, Pfizer, 3.375 gram, vial, 10 count, NDC 00409-3385-13
    • Piperacillin and Tazobactam powder for solution for injection, Pfizer, 3.375 gram, ADD-Vantage vial, 10 count, NDC 00409-3378-13
    • Piperacillin and Tazobactam powder for solution for injection, Pfizer, 4.5 gram, ADD-Vantage vial, 10 count, NDC 00409-3379-04
    • Piperacillin and Tazobactam powder for solution for injection, Pfizer, 4.5 gram, vial, 10 count, NDC 00409-3390-04
    • Piperacillin and Tazobactam powder for solution for injection, Sagent, 2.25 gram, vial, 10 count, NDC 25021-0164-30
    • Piperacillin and Tazobactam powder for solution for injection, Sagent, 3.375 gram, vial, 10 count, NDC 25021-0165-30
    • Piperacillin and Tazobactam powder for solution for injection, Sagent, 4.5 gram, vial, 10 count, NDC 25021-0166-48
    • Piperacillin and Tazobactam powder for solution for injection, Sandoz, 2.25 gram, vial, 10 count, NDC 00781-3110-95
    • Piperacillin and Tazobactam powder for solution for injection, Sandoz, 3.375 gram, vial, 10 count, NDC 00781-3113-95
    • Piperacillin and Tazobactam powder for solution for injection, Sandoz, 4.5 gram, vial, 10 count, NDC 00781-3114-95
    • Piperacillin and Tazobactam powder for solution for injection, WG Critical Care, 2.25 gram, vial, 10 count, NDC 44567-0801-10
    • Piperacillin and Tazobactam powder for solution for injection, WG Critical Care, 3.375 gram, vial, 10 count, NDC 44567-0802-10
    • Piperacillin and Tazobactam powder for solution for injection, WG Critical Care, 4.5 gram, vial, 10 count, NDC 44567-0803-10
    • Piperacillin and Tazobactam powder for solution for injection, WG Critical Care, 40.5 gram, bulk vial, 1 count, NDC 44567-0804-01
    • Piperacillin and Tazobactam powder for solution for injection, Wockhardt USA, 2.25 gram, vial, 10 count, NDC 64679-0034-01
    • Piperacillin and Tazobactam powder for solution for injection, Wockhardt USA, 3.375 gram, vial, 10 count, NDC 64679-0056-01
    • Piperacillin and Tazobactam powder for solution for injection, Wockhardt USA, 4.5 gram, vial, 10 count, NDC 64679-0012-01
    • Piperacillin and Tazobactam powder for solution for injection, Wockhardt USA, 40.5 gram, vial, 10 count, NDC 64679-0679-01
    • Piperacillin and Tazobactam powder for solution for injection, X-Gen, 2.25 gram, vial, 10 count, NDC 39822-0123-02
    • Piperacillin and Tazobactam powder for solution for injection, X-Gen, 3.375 gram, vial, 10 count, NDC 39822-0125-04
    • Piperacillin and Tazobactam powder for solution for injection, X-Gen, 4.5 gram, vial, 10 count, NDC 39822-0127-06
    • Piperacillin and Tazobactam powder for solution for injection, X-Gen, 40.5 gram, vial, 1 count, NDC 39822-0139-07

Estimated Resupply Dates

    • Auromedics has piperacillin/tazobactam 3.375 gram vials on intermittent back order and the company is releasing supplies as they become available.
    • Pfizer has Zosyn 2.25 gram vials, 3.375 gram vials, 4.5 gram vials, and 40.5 gram vials on back order and the company estimates a release date of March 2020. The piperacillin/tazobactam 2.25 gram ADD-Vantage vials are on back order and the company estimates a release date of September 2019.
    • Sagent has piperacillin/tazobactam 3.375 gram and 4.5 gram vials on back order and the company estimates a release date of August 2019. There are short-dated 2.25 gram vials available with an expiration date of October 2019.

Updated

Updated July 9, 2019 by Leslie Jensen, PharmD, Drug Information Specialist. Created February 5, 2014 by Leslie Jensen, PharmD, Drug Information Specialist. © 2019, Drug Information Service, University of Utah, Salt Lake City, UT.

Disclaimer

This information is provided through the support of Vizient to ASHP solely as a service to its members, which shall not use this information for their further commercial use. The content was prepared by the Drug Information Center of University of Utah. Vizient, ASHP, and the University of Utah make no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, which respect to such information, and specifically disclaim all such warranties. Users of this information are advised that decisions regarding the use of drugs and drug therapies are complex medical decisions and that in using this information, each user must exercise his or her own independent professional judgment. Neither Vizient, ASHP nor the University of Utah assumes any liability for persons administering or receiving drugs or other medical care in reliance upon this information, or otherwise in connection with this bulletin. Neither Vizient, ASHP nor University of Utah endorses or recommends the use of any drug.

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