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4/3/2020

Piperacillin and Tazobactam Injection

Products Affected - Description

    • Zosyn powder for solution for injection, Pfizer, 2.25 gram, vial, 10 count, NDC 00206-8852-16
    • Zosyn powder for solution for injection, Pfizer, 3.375 gram, vial, 10 count, NDC 00206-8854-16
    • Zosyn powder for solution for injection, Pfizer, 4.5 gram, vial, 10 count, NDC 00206-8855-16
    • Zosyn powder for solution for injection, Pfizer, 40.5 gram, bulk vial, 1 count, NDC 00206-8859-10
    • Piperacillin and Tazobactam powder for solution for injection, Apotex, 40.5 gram, bulk vial, 1 count, NDC 60505-0773-00
    • Piperacillin and Tazobactam powder for solution for injection, AuroMedics, 4.5 gram, vial, 10 count, NDC 55150-0121-50
    • Piperacillin and Tazobactam powder for solution for injection, Mylan Institutional, 4.5 gram, vial, 10 count, NDC 67457-0523-45
    • Piperacillin and Tazobactam powder for solution for injection, Wockhardt USA, 2.25 gram, vial, 10 count, NDC 64679-0034-01
    • Piperacillin and Tazobactam powder for solution for injection, Wockhardt USA, 3.375 gram, vial, 10 count, NDC 64679-0056-01
    • Piperacillin and Tazobactam powder for solution for injection, Wockhardt USA, 4.5 gram, vial, 10 count, NDC 64679-0012-01
    • Piperacillin and Tazobactam powder for solution for injection, Wockhardt USA, 40.5 gram, vial, 10 count, NDC 64679-0679-01
    • Piperacillin and Tazobactam powder for solution for injection, X-Gen, 2.25 gram, vial, 10 count, NDC 39822-0123-02 - discontinued
    • Piperacillin and Tazobactam powder for solution for injection, X-Gen, 3.375 gram, vial, 10 count, NDC 39822-0125-04 - discontinued
    • Piperacillin and Tazobactam powder for solution for injection, X-Gen, 4.5 gram, vial, 10 count, NDC 39822-0127-06 - discontinued
    • Piperacillin and Tazobactam powder for solution for injection, X-Gen, 40.5 gram, vial, 1 count, NDC 39822-0139-07 - discontinued

Reason for the Shortage

    • Apollo Pharmaceuticals has piperacillin/tazobactam injection available.
    • Apotex did not provide a reason for the shortage.
    • Athenex has piperacillin/tazobactam injection available.
    • AuroMedics did not provide a reason for the shortage.
    • Baxter has piperacillin/tazobactam injection available.
    • Fresenius Kabi has piperacillin/tazobactam injection available.
    • Mylan Institutional did not provide a reason for the shortage.
    • Pfizer has Zosyn single dose vials and piperacillin/tazobactam on shortage due to manufacturing delays.
    • Sagent has piperacillin/tazobactam injection available.
    • Sandoz has piperacillin/tazobactam injection available.
    • WG Critical Care has piperacillin/tazobactam available.
    • Wockhardt did not provide a reason for the shortage
    • X-Gen has discontinued all piperacillin/tazobactam presentations.

Available Products

    • Zosyn solution for injection, Baxter, 2.25 gram, 50 mL frozen premixed bag, 24 count, NDC 00206-8860-02
    • Zosyn solution for injection, Baxter, 3.375 gram, 50 mL frozen premixed bag, 24 count, NDC 00206-8861-02
    • Zosyn solution for injection, Baxter, 4.5 gram, 50 mL frozen premixed bag, 12 count, NDC 00206-8862-02
    • Piperacillin and Tazobactam powder for solution for injection, Apollo Pharmaceuticals, 13.5 gram, bulk vial, 1 count, NDC 61990-0140-01
    • Piperacillin and Tazobactam powder for solution for injection, Apollo Pharmaceuticals, 2.25 gram, vial, 10 count, NDC 61990-0110-02
    • Piperacillin and Tazobactam powder for solution for injection, Apollo Pharmaceuticals, 3.375 gram, vial, 10 count, NDC 61990-0120-02
    • Piperacillin and Tazobactam powder for solution for injection, Apollo Pharmaceuticals, 4.5 gram, vial, 10 count, NDC 61990-0130-02
    • Piperacillin and Tazobactam powder for solution for injection, Apollo Pharmaceuticals, 40.5 gram, bulk vial, 1 count, NDC 61990-0150-01
    • Piperacillin and Tazobactam powder for solution for injection, Apotex, 2.25 gram, vial, 10 count, NDC 60505-6156-04
    • Piperacillin and Tazobactam powder for solution for injection, Apotex, 3.375 gram, vial, 10 count, NDC 60505-6157-04
    • Piperacillin and Tazobactam powder for solution for injection, Apotex, 4.5 gram, vial, 10 count, NDC 60505-6159-04
    • Piperacillin and Tazobactam powder for solution for injection, Athenex, 2.25 gram, vial, 10 count, NDC 70860-0120-20
    • Piperacillin and Tazobactam powder for solution for injection, Athenex, 3.375 gram, vial, 10 count, NDC 70860-0121-30
    • Piperacillin and Tazobactam powder for solution for injection, Athenex, 4.5 gram, vial, 10 count, NDC 70860-0122-50
    • Piperacillin and Tazobactam powder for solution for injection, Athenex, 40.5 gram, vial, 1 count, NDC 70860-0123-99
    • Piperacillin and Tazobactam powder for solution for injection, AuroMedics, 2.25 gram, vial, 10 count, NDC 55150-0119-30
    • Piperacillin and Tazobactam powder for solution for injection, AuroMedics, 3.375 gram, vial, 10 count, NDC 55150-0120-30
    • Piperacillin and Tazobactam powder for solution for injection, Fresenius Kabi, 2.25 gram, vial, 10 count, NDC 63323-0981-21
    • Piperacillin and Tazobactam powder for solution for injection, Fresenius Kabi, 2.25 gram, vial, 10 count, NDC 63323-0309-20
    • Piperacillin and Tazobactam powder for solution for injection, Fresenius Kabi, 3.375 gram, vial, 10 count, NDC 63323-0300-30
    • Piperacillin and Tazobactam powder for solution for injection, Fresenius Kabi, 3.375 gram, vial, 10 count, NDC 63323-0983-21
    • Piperacillin and Tazobactam powder for solution for injection, Fresenius Kabi, 4.5 gram, vial, 10 count, NDC 63323-0320-50
    • Piperacillin and Tazobactam powder for solution for injection, Fresenius Kabi, 4.5 gram, vial, 10 count, NDC 63323-0982-52
    • Piperacillin and Tazobactam powder for solution for injection, Fresenius Kabi, 40.5 gram, bulk vial, 1 count, NDC 63323-0304-74
    • Piperacillin and Tazobactam powder for solution for injection, Mylan Institutional, 3.375 gram, vial, 10 count, NDC 67457-0522-37
    • Piperacillin and Tazobactam powder for solution for injection, Pfizer, 13.5 gram, vial, 1 count, NDC 00409-2999-14
    • Piperacillin and Tazobactam powder for solution for injection, Pfizer, 2.25 gram, vial, 10 count, NDC 00409-3383-02
    • Piperacillin and Tazobactam powder for solution for injection, Pfizer, 2.25 gram, ADD-Vantage vial, 10 count, NDC 00409-3374-02
    • Piperacillin and Tazobactam powder for solution for injection, Pfizer, 3.375 gram, vial, 10 count, NDC 00409-3385-13
    • Piperacillin and Tazobactam powder for solution for injection, Pfizer, 3.375 gram, ADD-Vantage vial, 10 count, NDC 00409-3378-13
    • Piperacillin and Tazobactam powder for solution for injection, Pfizer, 4.5 gram, vial, 10 count, NDC 00409-3390-04
    • Piperacillin and Tazobactam powder for solution for injection, Pfizer, 4.5 gram, ADD-Vantage vial, 10 count, NDC 00409-3379-04
    • Piperacillin and Tazobactam powder for solution for injection, Sagent, 2.25 gram, vial, 10 count, NDC 25021-0164-30
    • Piperacillin and Tazobactam powder for solution for injection, Sagent, 3.375 gram, vial, 10 count, NDC 25021-0165-30
    • Piperacillin and Tazobactam powder for solution for injection, Sagent, 4.5 gram, vial, 10 count, NDC 25021-0166-48
    • Piperacillin and Tazobactam powder for solution for injection, Sandoz, 2.25 gram, vial, 10 count, NDC 00781-3110-95
    • Piperacillin and Tazobactam powder for solution for injection, Sandoz, 3.375 gram, vial, 10 count, NDC 00781-3113-95
    • Piperacillin and Tazobactam powder for solution for injection, Sandoz, 4.5 gram, vial, 10 count, NDC 00781-3114-95
    • Piperacillin and Tazobactam powder for solution for injection, WG Critical Care, 2.25 gram, vial, 10 count, NDC 44567-0801-10
    • Piperacillin and Tazobactam powder for solution for injection, WG Critical Care, 3.375 gram, vial, 10 count, NDC 44567-0802-10
    • Piperacillin and Tazobactam powder for solution for injection, WG Critical Care, 4.5 gram, vial, 10 count, NDC 44567-0803-10
    • Piperacillin and Tazobactam powder for solution for injection, WG Critical Care, 40.5 gram, bulk vial, 1 count, NDC 44567-0804-01

Estimated Resupply Dates

    • Apotex has piperacillin/tazobactam 40.5 gram bulk vials on back order and the company cannot estimate a release date.
    • Auromedics has piperacillin/tazobactam 4.5 gram vials on intermittent back order and the company is releasing supplies as they become available.
    • Mylan Institutional has piperacillin/tazobactam 4.5 gram vials on back order and the company cannot estimate a release date.
    • Pfizer has Zosyn 2.25 gram, 3.375 gram, 4.5 gram, and 40.5 gram vials on back order and the company estimates a release date of February 2023.
    • Wockhardt has piperacillin/tazobactam 2.25 gram and 3.375 gram vials on allocation. The 4.5 gram and 40.5 gram vials are on back order and the company cannot estimate a release date.

Updated

Updated April 3, 2020 by Leslie Jensen, PharmD, Drug Information Specialist. Created February 5, 2014 by Leslie Jensen, PharmD, Drug Information Specialist. © 2020, Drug Information Service, University of Utah, Salt Lake City, UT.

Disclaimer

Drug Shortage Bulletins are copyrighted by the Drug Information Service of the University of Utah and provided by ASHP as its exclusive authorized distributor. ASHP and the University of Utah make no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information, and specifically disclaim all such warranties. Users of this information are advised that decisions regarding the use of drugs and drug therapies are complex medical decisions and that in using this information, each user must exercise his or her own independent professional judgment. Neither ASHP nor the University of Utah assumes any liability for persons administering or receiving drugs or other medical care in reliance upon this information, or otherwise in connection with this Bulletin. Neither ASHP nor the University of Utah endorses or recommends the use of any particular drug. Any application of this information for any purpose shall be limited to personal, non-commercial use.

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