|Postdural Puncture Headache2,5,6,7,8,9,10 ||Caffeine and Sodium Benzoate 500 mg in 1,000 mL normal saline infused over 1 hour, followed by 1,000 mL normal saline infused over 1 hour.|
A second dose may be given after 4 hours if necessary.
|Oral caffeine solution 300 mg as a single dose.|
Epidural sodium chloride 0.9% 24 hour infusion or 20-30 mL injection.
|Conservative measures such as bed rest, analgesics, and oral hydration are recommended for the first 24-48 hours. An epidural blood patch is a treatment option for severe headaches or if conservative measures fail.|
The effects of both intravenous and oral caffeine are transient and the headache may return.
|Electroconvulsive Therapy2,11,12,13,14,15,16,17 ||Caffeine and Sodium Benzoate 500 mg (maximum of 2000 mg) intravenous infused over 20-30 seconds 5 minutes prior to electrical stimulation.||Aminophylline 3-5 mg/kg intravenous 10 minutes prior to electrical stimulation|
Theophylline 200-400 mg sustained-release tablets orally 10 hours prior to electrical stimulation13,15,17
Theophylline injection 100-200 mg intravenous over several minutes, given 30 minutes prior to electrical stimulation16
|Theophylline may cause status epilepticus in patients with slightly higher than therapeutic plasma concentrations.|