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6/20/2018

Asparaginase Erwinia chrysanthemi

Reason for the Shortage

    • Jazz has Erwinaze available.

Available Products

    • Erwinaze, Jazz Pharmaceuticals, 10,000 unit, 3 mL vial, 5 count, NDC 57902-0249-05

Estimated Resupply Dates

    • Jazz Pharmaceuticals has Erwinaze available.

Safety

    • Jazz Pharmaceuticals sent Dear Health Care Provider letters regarding the administration of certain batches of Erwinaze (Batches 174K, 177K, 178K, 179K, 180K, 181K, 182K, 183K, 184K, 185ak, 186). Particulate matter was seen in vials from these batches during routine inspections. Jazz states that these batches must be given intramuscularly only and NOT intravenously. Batch 187K may be given either intramuscularly or intravenously via tubing with a 0.2-micron, low-protein-binding, in-line filter. Use 5-micron filter needles when withdrawing Erwinaze from vials. The most recent letter with further details can be found at https://www.fda.gov/downloads/Drugs/DrugSafety/DrugShortages/UCM607844.pdf and https://erwinazesupply.com/wp-content/uploads/2018/05/Erwinaze-CAMR187_DHCP_clean.pdf.

Updated

Updated June 20, 2018 by Leslie Jensen, PharmD, Drug Information Specialist. Created October 11, 2016 by Elyse MacDonald, PharmD, MS, BCPS. Copyright 2018, Drug Information Service, University of Utah, Salt Lake City, UT.

Disclaimer

This information is provided through the support of Vizient to ASHP solely as a service to its members, which shall not use this information for their further commercial use. The content was prepared by the Drug Information Center of University of Utah. Vizient, ASHP, and the University of Utah make no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, which respect to such information, and specifically disclaim all such warranties. Users of this information are advised that decisions regarding the use of drugs and drug therapies are complex medical decisions and that in using this information, each user must exercise his or her own independent professional judgment. Neither Vizient, ASHP nor the University of Utah assumes any liability for persons administering or receiving drugs or other medical care in reliance upon this information, or otherwise in connection with this bulletin. Neither Vizient, ASHP nor University of Utah endorses or recommends the use of any drug.

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