Skip to main content Back to Top
Advertisement

3/20/2019

Multiple Electrolytes Large Volume Solutions for Injection

Reason for the Shortage

    • Baxter has Plasma-Lyte 148 and Plasma-Lyte A presentations available.
    • ICU Medical had Normosol-R presentations on back order due to manufacturing delays.

Available Products

    • Normosol-R solution for injection, ICU Medical, 1000 mL bag, NDC 00409-7967-09
    • Normosol-R pH 7.4 solution for injection, ICU Medical, 1,000 mL bag, NDC 00409-7670-09
    • Normosol-R pH 7.4 solution for injection, ICU Medical, 500 mL bag, NDC 00409-7670-03
    • Plasma-Lyte 148 solution for injection, Baxter, 1,000 mL bag, NDC 00338-0179-04
    • Plasma-Lyte 148 solution for injection, Baxter, 500 mL bag, NDC 00338-0179-03
    • Plasma-Lyte A solution for injection, Baxter, 1,000 mL bag, NDC 00338-0221-04
    • Plasma-Lyte A solution for injection, Baxter, 500 mL bag, NDC 00338-0221-03

Alternative Agents & Management

  • Table 1. Comparison of Multiple Electrolytes Large Volume Solutions for Injection1-4

    Plasma-Lyte 148
    Plasma-Lyte-A
    (nonpyrogenic, isotonic)
    Normosol-R
    Contents (per 100 mL)Sodium chloride - 526 mg
    Sodium gluconate - 502 mg
    Sodium acetate trihydrate - 368 mg
    Potassium chloride - 37 mg
    Magnesium chloride - 30 mg
    Sodium chloride - 526 mg
    Sodium gluconate - 502 mg
    Sodium acetate - 222 mg
    Potassium chloride - 37 mg
    Magnesium chloride, hexahydrate - 30 mg
    Ionic concentrations (per 1 L)Sodium - 140 mEq
    Potassium - 5 mEq
    Magnesium - 3 mEq
    Chloride - 98 mEq
    Acetate - 27 mEq
    Gluconate - 23 mEq
    Sodium - 140 mEq
    Potassium - 5 mEq
    Magnesium - 3 mEq
    Chloride - 98 mEq
    Acetate - 27 mEq
    Gluconate - 23 mEq
    Osmolarity294 mOsmol/L294 - 295 mOsmol/L
    pH5.5 (Plasma-Lyte 148)
    7.4 (Plasma-Lyte-A)
    6.6 (Normosol-R)
    7.4 (Normosol-R pH 7.4)
    Caloric content21 kcal/LNot specified in package insert
    Labeled indicationsSource of water and electrolytes
    Alkalinizing agent
    Replacement of acute extracellular fluid volume losses in surgery, trauma, burns, or shock
    Adjunct to restore decreased circulatory volume

References

    1. Plasma-Lyte 148 [package insert]. Deerfield, IL: Baxter Healthcare; 2017.
    2. Plasma-Lyte A [package insert]. Deerfield, IL: Baxter Healthcare; 2017.
    3. Normosol-R [package insert]. Lake Forest, IL: Hospira; 2009.
    4. Normosol-R pH 7.4 [package insert]. Lake Forest, IL: Hospira; 2009.

Updated

Updated March 20, 2019 by Leslie Jensen, PharmD, Drug Information Specialist. Created February 1, 2018 by Elyse MacDonald, PharmD, MS, BCPS. © 2019, Drug Information Service, University of Utah, Salt Lake City, UT.

Disclaimer

This information is provided through the support of Vizient to ASHP solely as a service to its members, which shall not use this information for their further commercial use. The content was prepared by the Drug Information Center of University of Utah. Vizient, ASHP, and the University of Utah make no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, which respect to such information, and specifically disclaim all such warranties. Users of this information are advised that decisions regarding the use of drugs and drug therapies are complex medical decisions and that in using this information, each user must exercise his or her own independent professional judgment. Neither Vizient, ASHP nor the University of Utah assumes any liability for persons administering or receiving drugs or other medical care in reliance upon this information, or otherwise in connection with this bulletin. Neither Vizient, ASHP nor University of Utah endorses or recommends the use of any drug.

« Back to Drug Shortage Product Bulletins