Skip to main content Back to Top
Advertisement

Sepsis

Articles

Antimicrobial Therapy

Empiric antibiotic treatment reduces mortality in severe sepsis and septic shock from the first hour: results from a guidelines-based performance improvement program [Crit Care Med 2014]

Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock [Crit Care Med 2006]\

The impact of timing of antibiotics on outcomes in severe sepsis and septic shock: a systematic review and meta-analysis [Crit Care Med 2015]

Fluids

Choice of resuscitative fluids and mortality in emergency department patients with sepsis [Am J Emerg Med 2017]

What is the Preferred Resuscitation Fluid for Patients with Severe Sepsis and Septic Shock? [J Emerg Med 2017]

Goal Directed Therapy/Protocol Directed Therapy

A randomized trial of protocol-based care for early septic shock [N Engl J Med 2014]

Goal-directed resuscitation for patients with early septic shock [N Engl J Med 2014]

Trial of early, goal-directed resuscitation for septic shock [N Engl J Med 2015]

Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock [N Engl J Med 2001]

Triage sepsis alert and sepsis protocol lowers timers to fluids and antibiotics in the ED [Am J Emerg Med 2016]

National early warning score at Emergency Department triage may allow earlier identification of patients with severe sepsis and septic shock: a retrospective observational study [Emerg Med J 2016]

A randomized trial of protocol-based care for early septic shock (ProCESS) [N Engl J Med 2014]

Goal-directed resuscitation for patients with early septic shock (ARISE) [NEJM 2014]

Steroids

Single-dose etomidate does not increase mortality in patients with sepsis. A systematic review and meta-analysis of randomized controlled trials and observational studies [Chest 2015]

Hydrocortisone therapy for patients with septic shock [N Engl J Med 2008]

Early initiation of low-dose hydrocortisone treatment for septic shock in adults: A randomized clinical trial [Am J Emerg Med 2017]

Hydrocortisone therapy for patients with septic shock [N Engl J Med 2008]

Vasopressors

Vasopressin versus Norepinephrine Infusion in Patients with Septic Shock [N Engl J Med 2008]

Comparison of Dopamine and Norepinephrine in the Treatment of Shock [N Engl J Med 2010]

High versus low blood-pressure target in patients with septic shock [N Engl J Med 2014]

Guidelines

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) [JAMA]

Member Only

Join ASHP today to get access to the full content

ASHP Connect communities

ASHP Connect

ASHP Connect communities, discussions, and blogs devoted to pharmacy practice

Go to Connect
Link the whole card

About ASHP

We represent pharmacists who serve as patient care providers in acute and ambulatory settings.

Read More
Link the whole card

Join / Renew

Join ASHP or renew your membership to take advantage of our benefits, services and resources
View Benefits
Link the whole card