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Yellow Fever Vaccine

Products Affected - Description

    • YF-Vax subcutaneous powder for suspension for injection, Sanofi Pasteur, Multiple-dose vial (5 doses per vial) with diluent 1 count, NDC 49281-0915-05
    • YF-Vax subcutaneous powder for suspension for injection, Sanofi Pasteur, Single-dose vial with diluent, 5 count, NDC 49281-0915-01

Reason for the Shortage

    • Sanofi Pasteur states the shortage of YF-Vax is due to production delays. [1]
    • There are no other suppliers of yellow fever vaccine.
    • Additional information on the yellow fever shortage is available at

Available Products

    • There are no presentations available

Estimated Resupply Dates

    • Sanofi Pasteur has YF-Vax multi-dose vials and single dose vials on back order and the company estimates product will be available in 2021.[1]
    • Sanofi Pasteur has worked with FDA to make another vaccine, Stamaril, available in the US under an investigational new drug program. Stamaril is yellow fever vaccine manufactured by Sanofi Pasteur in France. It is not licensed in the US. Under the program, Stamaril is supplied to a limited number of clinics. Clinics providing access to Stamaril can be found at More information can be found at or at
    • Stamaril is on allocation due to supply demand.[1]

Implications for Patient Care

    • Yellow fever vaccine must be used within 1 hour of reconstitution. Practitioners should consider scheduling several patients for immunization simultaneously to conserve use of YF-Vax 5-dose vials.[2]

Alternative Agents & Management

    • Information on countries that require yellow fever vaccination can be found at


    1. Sanofi Pasteur, Customer Service (personal communication and website). November 24 and December 15, 2015; January 13, February 3, March 22, April 18, May 31, July 20, September 27, and November 29, 2016; January 31, March 27, June 27, August 29, November 1, December 15, 2017; February 7, April 11, June 11, August 1, October 25, 2018; and January 30, April 15 and 26, July 9, October 9, November 11, December 18, 2019; January 14, April 16, June 30, September 3, and December 23, 2020.
    2. Yellow Fever Vaccine (YF-Vax). Product information. Swiftwater, PA: Sanofi Pasteur, 2014 March.


Updated December 23, 2020 by Leslie Jensen, PharmD, Drug Information Specialist. Created November 24, 2015 by Leslie Jensen, PharmD, Drug Information Specialist. © 2020, Drug Information Service, University of Utah, Salt Lake City, UT.



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