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C1-Esterase Inhibitor (Human) Injection

Reason for the Shortage

    • CSL Behring has Berinert available. The company is shipping weekly to distributors.
    • Shire has resumed manufacturing and Cinryze is available.
    • The subcutaneous dosage form of C1-esterase inhibitor (human) is unaffected by this shortage.

Available Products

    • Berinert intravenous injection, CSL Behring, 500 unit, preservative-free vial, NDC 63833-0825-02
    • Cinryze intravenous injection, Shire, 500 unit, preservative-free vial, NDC 42227-0081-05

Implications for Patient Care

    • The following lots require filtering prior to administering: 17F19L37OA, 17F24L370A, 17G10L370A, 17G16L370A, 17G21L370A, 17H12L370A, 17G26L370A and 17H22L370A. Additional information and self-administration instructions are available at


Updated June 13, 2019 by Anthony Trovato, PharmD, BCPS. Created August 16, 2017 by Benjamin Witt, PharmD, BCPS, Drug Information Specialist. © 2019, Drug Information Service, University of Utah, Salt Lake City, UT.


Drug Shortage Bulletins are copyrighted by the Drug Information Service of the University of Utah and provided by ASHP as its exclusive authorized distributor. ASHP and the University of Utah make no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information, and specifically disclaim all such warranties. Users of this information are advised that decisions regarding the use of drugs and drug therapies are complex medical decisions and that in using this information, each user must exercise his or her own independent professional judgment. Neither ASHP nor the University of Utah assumes any liability for persons administering or receiving drugs or other medical care in reliance upon this information, or otherwise in connection with this Bulletin. Neither ASHP nor the University of Utah endorses or recommends the use of any particular drug. Any application of this information for any purpose shall be limited to personal, non-commercial use.

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