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5/26/2023

Methotrexate Injection

Products Affected - Description

    • Methotrexate injection, Accord, 25 mg/mL, 10 mL preservative-free vial, 1 count, NDC 16729-0277-03
    • Methotrexate injection, Accord, 25 mg/mL, 2 mL preservative-free vial, 1 count, NDC 16729-0277-30
    • Methotrexate injection, Accord, 25 mg/mL, 40 mL preservative-free vial, 1 count, NDC 16729-0277-35
    • Methotrexate injection, Fresenius Kabi, 25 mg/mL, 10 mL (with preservative) vial, 1 count, NDC 63323-0123-10
    • Methotrexate, Fresenius Kabi, 1 gram, vial, 1 count, NDC 63323-0122-50
    • Methotrexate injection, Hikma, 25 mg/mL, 2 mL preservative-free vial, 10 count, NDC 00143-9519-10
    • Methotrexate, Hikma, 1 gram, vial, 1 count, NDC 00143-9830-01
    • Methotrexate injection, Pfizer, 25 mg/mL, 2 mL (with preservative) vial, 5 count, NDC 61703-0350-38
    • Methotrexate injection, Pfizer, 25 mg/mL, 40 mL preservative-free vial, 1 count, NDC 61703-0408-41
    • Methotrexate injection, Teva, 25 mg/mL, 10 mL preservative-free vial, 1 count, NDC 00703-3675-01
    • Methotrexate injection, Teva, 25 mg/mL, 2 mL preservative-free vial, 1 count, NDC 00703-3671-01
    • Methotrexate injection, Teva, 25 mg/mL, 40 mL preservative-free vial, 1 count, NDC 00703-3678-01

Reason for the Shortage

    • Accord has methotrexate injection on shortage due to manufacturing delays.
    • Fresenius Kabi has methotrexate injection on back order due to increased demand.
    • Pfizer has methotrexate injection on back order due to increased demand.
    • Teva did not provide a reason for the shortage.
    • Hikma has methotrexate injection on back order due to increased demand.

Available Products

    • There is insufficient supply for usual ordering

Estimated Resupply Dates

    • Accord has methotrexate 25 mg/mL 2 mL, 10 mL, and 40 mL preservative-free vials on back order and the company cannot estimate a release date.
    • Fresenius Kabi has methotrexate 25 mg/mL 10 mL preservative-free vials on back order and the company estimates a release date of early-June 2023. The 1 gram lyophilized powder vials are on back order and the company estimates a release date of late-May to early-June 2023.
    • Hikma has methotrexate 25 mg/mL 2 mL preservative-free vials on allocation. The 1 gram lyophilized powder vials are back order and the company estimates a release date of late-June 2023.
    • Pfizer has methotrexate 25 mg/mL 2 mL vials and 40 mL preservative-free vials available in limited supply.
    • Teva has methotrexate 25 mg/mL 2 mL, 10 mL, and 40 mL preservative-free vials on back order and the company estimates a release date of May 2023.

Updated

Updated May 26, 2023 by Michelle Wheeler, PharmD, Drug Information Specialist. Created February 2, 2023 by Leslie Jensen, PharmD, Drug Information Specialist. © 2023, Drug Information Service, University of Utah, Salt Lake City, UT.

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