Phytonadione I.V. Beats S.C. at Lowering INR
Researchers evaluated the effect of phytonadione 1 mg administered i.v. or s.c. to 22 patients with an INR greater than 6 but with no symptoms of bleeding. Eight hours after the injection, patients who received the i.v. dose had a significantly greater decrease in INR than did the patients in the other group. Although s.c. injection of phytonadione was effective, its action was not as quick as with the i.v. dose.