2/7/2023

Iohexol Injection

Reason for the Shortage

- GE Healthcare has Omnipaque available.

Available Products

- Omnipaque oral solution, GE Healthcare, 12 mg/mL, 500 mL +PLUSPAK bottle, 10 count, NDC 00407-1416-12
- Omnipaque oral solution, GE Healthcare, 9 mg/mL, 500 mL +PLUSPAK bottle, 10 count, NDC 00407-1415-09
- Omnipaque solution for injection, GE Healthcare, 180 mg/mL, 20 mL glass vial, 10 count, NDC 00407-1411-20
- Omnipaque solution for injection, GE Healthcare, 300 mg/mL, 10 mL glass vial, 10 count, NDC 00407-1413-10
- Omnipaque solution for injection, GE Healthcare, 300 mg/mL, 100 mL +PLUSPAK bottle, 10 count, NDC 00407-1413-63
- Omnipaque solution for injection, GE Healthcare, 300 mg/mL, 100 mL +PLUSPAK bottle, 10 count, NDC 00407-1413-87
- Omnipaque solution for injection, GE Healthcare, 300 mg/mL, 150 mL fill in 200 mL +PLUSPAK bottle, 10 count, NDC 00407-1413-65
- Omnipaque solution for injection, GE Healthcare, 300 mg/mL, 200 mL +PLUSPAK bottle, 10 count, NDC 00407-1413-66
- Omnipaque solution for injection, GE Healthcare, 300 mg/mL, 30 mL fill in 50 mL +PLUSPAK bottle, 10 count, NDC 00407-1413-59
- Omnipaque solution for injection, GE Healthcare, 300 mg/mL, 50 mL +PLUSPAK bottle, 10 count, NDC 00407-1413-61
- Omnipaque solution for injection, GE Healthcare, 300 mg/mL, 500 mL +PLUSPAK bottle, 10 count, NDC 00407-1413-72
- Omnipaque solution for injection, GE Healthcare, 300 mg/mL, 500 mL +PLUSPAK bottle, 10 count, NDC 00407-1413-68
- Omnipaque solution for injection, GE Healthcare, 300 mg/mL, 500 mL +PLUSPAK bottle, 10 count, NDC 00407-1413-89
- Omnipaque solution for injection, GE Healthcare, 300 mg/mL, 75 mL fill in 100 mL +PLUSPAK bottle, 10 count, NDC 00407-1413-62
- Omnipaque solution for injection, GE Healthcare, 350 mg/mL, 100 mL +PLUSPAK bottle, 10 count, NDC 00407-1414-91
- Omnipaque solution for injection, GE Healthcare, 350 mg/mL, 125 mL fill in 150 mL glass bottle, 10 count, NDC 00407-1414-76
- Omnipaque solution for injection, GE Healthcare, 350 mg/mL, 200 mL +PLUSPAK bottle, 10 count, NDC 00407-1414-94
- Omnipaque solution for injection, GE Healthcare, 350 mg/mL, 50 mL +PLUSPAK bottle, 10 count, NDC 00407-1414-89
- Omnipaque solution for injection, GE Healthcare, 350 mg/mL, 500 mL +PLUSPAK bottle, 10 count, NDC 00407-1414-72

Estimated Resupply Dates

- All marketed presentations are available.

Alternative Agents & Management

More information can be found at Considerations for Imaging Contrast Shortage Management and Conservation
Non-ionic, low osmolality contrast media in current use include iopamidol, iohexol, iopromide, and ioversol.
Iodixanol (iso-osmolality agent) is also included in the low osmolality contrast media category.[1]
Table 1 lists specifications of iodinated intravascular contrast media products.
The American College of Radiology (ACR) has issued a statement addressing the shortage of iodinated contrast media. https://www.acr.org/Advocacy-and-Economics/ACR-Position-Statements/Contrast-Media-Shortage

Table 1. Table 1 Specifications of Iodinated Intravascular Contrast Media1
Product	Generic name (concentration)	Ionicity	Iodine (mg/mL)	Viscosity at 20 - 25 degrees C (cps)	Viscosity at 37 degrees C (cps)	Osmolality (mOsm/kg of water)
Omnipaque 140	Iohexol (302)	Nonionic	140	2.3	1.5	322
Ultravist 150	iopromide	Nonionic	150	2.3	1.5	328
Omnipaque 180	iohexol (388)	Nonionic	180	3.1	2	408
Isovue 200	iopamidol (408)	Nonionic	200	3.3	2.0	413
Omnipaque 240	iohexol (518)	Nonionic	240	5.8	3.4	520
Ultravist 240	iopromide	Nonionic	240	4.9	2.8	483
Isovue 250	iopamido (510)	Nonionic	250	5.4	3.0	524
Visipaque 270	iodixanol (550)	Nonionic	270	12.7	6.3	290
Conray	iothalamate (600)	Ionic	282	6	4	1400
Isovue 300	iopamidol (612)	Nonionic	300	8.8	4.7	616
Omnipaque 300	iohexol (647)	Nonionic	300	11.8	6.3	672
Optiray 300	ioversol (640)	Nonionic	300	8.2	5.5	651
Ultravist 300	iopromide	Nonionic	300	9.2	4.9	607
Optiray 320	ioversol (680)	Nonionic	320	9.9	5.8	702
Visipaque 320	iodixanol (652)	Nonionic	320	26.6	11.8	290
Optiray 350	ioversol (740)	Nonionic	350	14.3	9.0	792
Omnipaque 350	iohexol (755)	Nonionic	350	20.4	10.4	844
Isovue 370	iopamidol (755)	Nonionic	370	20.9	9.4	796
Ultravist 370	Iopromide	Nonionic	370	22.0	10.0	774

References

1. ACR Manual on Contrast Media. American College of Radiology. https://www.acr.org/-/media/ACR/Files/Clinical-Resources/Contrast_Media.pdf. 2021.

Updated

Updated February 7, 2023 by Michelle Wheeler, PharmD, Drug Information Specialist. Created April 29, 2022 by Leslie Jensen, PharmD, Drug Information Specialist. © 2023, Drug Information Service, University of Utah, Salt Lake City, UT.

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