Articles
- Drug Disposition, Drug Targets, and Side Effects, N Engl J Med (2003)
- Cancer Genome Landscapes, Science (2013)
- New Initiative on Precision Medicine, N Engl J Med (2015)
- PG4KDS: A model for the clinical implementation of pre-emptive pharmacogenetics, Am J Med Genet C Semin Med Genet (2014)
- Pharmacogenomics in the clinic., Nature (2015)
- Clinical Trials is pharmacogenetics and Pharmacogenomics: Methods and Applications, AJHP (2000)
- Development and implementation of a pharmacist-managed clinical pharmacogenetics service, AJHP (2011)
- Common Laboratory Methods in Pharmacogenomics Studies, AJHP (2006)
- Genetic Basis of Drug Metabolism, AJHP (2002)
- Pharmacogenetics: from discovery to patient care, AJHP (2009)
- Pharmacogenomics and infectious diseases: Impact on drug response and applications to disease management, AJHP (2002)
- Pharmacogenomics of warfarin: Uncovering a piece of the warfarin mystery, AJHP (2009)
- Pharmacogenomic biomarkers: new tools in current and future drug therapy, Trends Pharmacol Sci(2011)
- Developmental pharmacogenomics, Paediatr Anaesth (2011)
- Clinical assessment incorporating a personal genome, Lancet (2010)
- Pharmacogenomics: Bridging the gap between science and practice, J Am Pharm Assoc (2003)
Guidelines
- Clinical Pharmacogenetics Implementation Consortium (CPIC®) Guidelines: CPIC guidelines are designed to help clinicians understand HOW available genetic test results should be used to optimize drug therapy, rather than WHETHER tests should be ordered. A key assumption underlying the CPIC guidelines is that clinical high-throughput and pre-emptive (pre-prescription) genotyping will become more widespread, and that clinicians will be faced with having patients’ genotypes available even if they have not explicitly ordered a test with a specific drug in mind. ASHP reviews and endorses select guidelines on an annual basis.
Below are the CPIC guidelines currently endorsed by ASHP:
- CPIC Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Tricyclic Antidepressants
- CPIC Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors
- CPIC Guideline for Thiopurine Methyltransferase Genotype and Thiopurine Dosing
- CPIC Guidelines for Codeine Therapy in the Context of Cytochrome P450 2D6 (CYP2D6) Genotype
- CPIC Guideline for Cytochrome P450-2C19 Genotype and Clopidogrel Therapy
- CPIC Guideline for HLA-B Genotype and Abacavir Dosing
- CPIC Guideline for SLCO1B1 and Simvastatin-Induced Myopathy
- CPIC Guideline for CYP3A5 genotype and Tacrolimus Dosing
- CPIC Guideline for Allopurinol and HLA-B
- CPIC Guideline for Pharmacogenetics-Guided Warfarin Dosing
- CPIC Guideline for Phenytoin and CYP2C9 and HLA-B
- My Drug Genome, Vanderbilt University
