Pharmacogenomic Resources
- My Drug Genome: Vanderbilt University has launched PREDICT (Pharmacogenomic Resource for Enhanced Decisions in Care & Treatment), which empowers patients and doctors with the genetic information needed to predict and help prevent bad drug side effects.
- Pharmacogenomics Knowledge Base: The Pharmacogenomics Knowledgebase (PharmGKB) is an NIH-funded resource that provides information about how human genetic variation affects response to medications. PharmGKB collects, curates and disseminates knowledge about clinically actionable gene-drug associations and genotype-phenotype relationships.
- Table of Pharmacogenomic Biomarkers in Drug Labels:This table from the FDA lists therapeutic products from Drugs@FDA with pharmacogenomic information found in the drug labeling. The labeling for some, but not all, of the products includes specific actions to be taken based on the biomarker information. Pharmacogenomic information can appear in different sections of the labeling depending on the actions.
- Pharmacogenetics Research Network, The NIH Pharmacogenomics Research Network (PGRN) is a network of scientists focused on understanding how a person's genes affect his or her response to medicines.
- Pharmacogene Variation (PharmVar) Consortium: The Pharmacogene Variation (PharmVar) Consortium is a central repository for pharmacogene (PGx) variation that focuses on haplotype structure and allelic variation. The information in this resource facilitates the interpretation of pharmacogenetic test results to guide precision medicine.
- PharmGenEd, Pharmacogenomics Education Program-University of California San Diego
- CDC’s Office of Public Health Genomics (OPHG): OPHG conducts and supports workshops, courses, and other training activities in public health genomics, family history, and human genome epidemiology. OPHG was also involved in developing genomics competencies for public health professionals.
- Mayo Clinic Center for Individualized Medicine
- Global Generics and Genomics Community (National Human Genome Research Institute)
Pharmacogenomic Competencies
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database
- Implementation Resources for Healthcare Professionals, St. Jude Children’s Research Hospital
- Introduction to Pharmacogenetics Competency, [PDF]
- Thiopurine S-Methyltransferase (TPMT): Advanced Pharmacogenetic Competency, [PDF]
- Cytochrome P450 2D6 (CYP2D6) Pharmacogenetic Competency, [PDF]
- Cytochrome P450 2C19 (CYP2C19) Pharmacogenetic Competency, [PDF]
- SLCO1B1 Pharmacogenetic Competency, [PDF]
- Dihydropyridine Dehydrogenase (DPYD) Pharmacogenetic Competency, [PDF]
- Uridine Diphosphate Glucuronosyltransferase 1A1 (UGT1A1) Pharmacogenetic Competency, [PDF]
- Genetics/Genomics Competency Center (National Human Genome Research Institute)
Genetic Research/Genome Resources
- National Human Genome Research Institute, NIH: NCHGR expanded its role on the NIH campus by establishing the Division of Intramural Research to apply genome technologies to the study of specific diseases. In 1996, the Center for Inherited Disease Research (CIDR) was also established (co-funded by eight NIH institutes and centers) to study the genetic components of complex disorders.In 1997 the United States Department of Health and Human Services renamed NCHGR the National Human Genome Research Institute (NHGRI), officially elevating it to the status of research institute - one of 27 institutes and centers that make up the NIH.
- Public Health Genomics, CDC:CDC’s Office of Public Health Genomics (OPHG) has served CDC programs, other federal agencies, state health departments, and other external partners by identifying, evaluating, and implementing evidence-based genomics practices to prevent and control the country’s leading chronic, infectious, environmental, and occupational diseases.
- Genomics, FDA: The Genomics and Targeted Therapy Group is located within FDA’s Office of Clinical Pharmacology and works to apply pharmacogenomics and other biomarkers in drug development and clinical practice. FDA scientists work in multiple ways to ensure that pharmacogenomic strategies are applied appropriately in all phases of drug development. Core functions include regulatory review, research, policy development, and education and outreach.
- Genetic Information Research Institute: Mission is to understand the process altering the genetic makeup of different organism as well as their biological and medical impact.
- The Biomarkers Consortium: The Biomarkers Consortium is a public-private biomedical research partnership managed by the Foundation for the National Institutes of Health that endeavors to discover, develop, and seek regulatory approval for biological markers (biomarkers) to support new drug development, preventive medicine, and medical diagnostics.
- Gene Therapy Clinical Trials Worldwide: The Journal of Gene Medicine Clinical Trial site, it includes sources of information on worldwide gene therapy clinical trials available on the internet.
- Human Genome Project Information: The U.S. Department of Energy's Genomic Science program (formerly Genomics:GTL) uses microbial and plant genomic data, high-throughput analytical technologies, and modeling and simulation to develop a predictive understanding of biological systems behavior relevant to solving energy and environmental challenges.
- The Sanger Institute (UK): The Institute is a center-stage, world leader in genome research and aims to deliver new insights into human and pathogen biology that change the course of biology and medicine.
- Current Genome Map, NIH
- Genome Hub, NIH
- Genetic Information, USDHHS
- Genetic Testing Registry, NIH
Genetic Disease Information
- The Genetics Alliance
- National Organization for Rare Disorders
- Office of Rare Diseases (NIH)
- Kansas University Medical Center
- National Cancer Institute
- Genetic Disease Foundation
- Genetics Disorders Library
Ethical, Legal, and Social
- Ethical, Legal, and Social Implications of Human Genetics Research
- Council for Responsible Genetics
- Genetic Information Discrimination
- ELSI Research Program
Sequencing Centers
- Broad Institute of MIT and Harvard Genome Center
- Washington University Genome Sequencing Center
- Baylor College of Medicine Human Genome Sequencing Center
- Department of Energy (DOE) Joint Genome Institute
- University of Washington Genome Center
- Max Planck Institute for Molecular Genetics, Germany
- Brigham Young University DNA Sequencing Center
- University of Chicago Cancer Research Center
- HudsonAlpha Institute for Biotechnology
SNP (Single Nucleotide Polymorphisms) Information
- SNPits, University of Florida
- National Center for Biotechnology Information
Journals
- Gene Therapy Journal
- The Pharmacogenomics Journal
- Future Medicine-Pharmacogenomics
- American Journal of Pharmacogenomics
